Combating Food Fraud with MISA

Food fraud, adulteration, and tampering is more common than you might think.

Metrohm has developed a simple, efficient, green testing solution to food safety threats.

Misa (Metrohm Instant SERS Analyser) is a portable analyser that applies Surface-Enhanced Raman Scattering to deliver results instantly, reliably, and easily.

MISA: Key features

  • Instant results
  • Straightforward operation, no chemistry know-how required
  • Intuitive guided workflows
  • Green chemistry – reduce the amount of chemicals and solvents used
  • Operation via mobile app or laptop computer
  • Complete trace detection solution

The possibilities of MISA: applications for food quality testing

Samples for food safety testing with Misa Metrohm Instant SERS Analyzer

Fruits and vegetables:


Meats and dairy:

Antibiotics and growth hormones


Artificial dyes

Processed foods:

Illegal/harmful additives

Simple, efficient, and green: food testing with MISA

With MISA, you can run fully automated analyses to identify trace contaminants even within complex food samples quickly and accurately.

Streamline your workflow. MISA simplifies testing to an easy process:

  1. Prepare the sample
  2. Apply the sample to the SERS test materials
  3. Acquire the signal
  4. Read and share the results

MISA Cal M app: a powerful mobile platform for food testing

MISA can be operated using a computer, tablet, or mobile phone and allows you to take immediate action if you have found tainted food. This mobile platform provides critical information about potentially dangerous substances.

  • Simple testing
  • Quality results
  • Clear warnings
  • Visual evidence
  • Geo-tagging
  • Share alerts

Misa Cal M app for fast food testing
Misa Cal M app for food quality testing using SERS
Food quality testing with Metrohm Instant SERS Analyzer

How do MISA and Surface-Enhanced Raman Scattering work?

Contamination of food is a global problem, whether it is done intentionally for profit or accidentally through negligence, the end result is the same – consumers pay the price.

The problem of food contamination can be addressed with complex analytical laboratory techniques such as GC-MS and HPLC, but time, skill, and cost requirements limits their usage to the confines of well-equipped laboratories. Surface Enhanced Raman Scattering (SERS) – an extension of Raman spectroscopy - permits detection and identification of analytes in concentrations as low as parts per billion. Food analysis with SERS can be fast, convenient, and inexpensive.

Misa SERS analyzer for food quality testing

SERS utilizes nanotechnology with Raman spectroscopy to enable trace detection of adsorbed molecules. When a sample is applied to Metrohm’s SERS material, the nanostructures generate millions of times enhancement to Raman scattering, and detection of trace-levels of analytes is readily achievable. SERS is an extremely attractive technique as it retains all of the appealing features of Raman – portable equipment, multi-analyte detection capabilities, and rapid analysis.

MISA from Metrohm is a dedicated instrument for performing SERS measurements. MISA was developed with the focus for a simple, efficient and green testing solution to address food safety threats. Easily swappable attachments allows flexibility of testing using different types of SERS materials. Metrohm also provides targeted ID Kits that include test materials as well as detailed step-by-step instructions for measurement of common contaminants in various food matrices. 


Contact us for more information about Misa