What are the advantages of Raman spectroscopy for process monitoring?

Raman spectroscopy offers numerous advantages for process monitoring: «Real-time» results: It enables instant insights into molecular changes during processes, providing timely feedback for adjustments Non-destructive analysis: Raman spectroscopy is a non-invasive method that analyzes samples without causing any damage, safeguarding the original state of the monitored substances. Identification of molecular species: It effectively detects impurities, intermediates, or by-products, supporting with quality assurance and control and ensuring product consistency Inline process control: Raman spectroscopy allows for direct monitoring of process parameters, allowing for real-time adjustments to maintain desired production conditions.

Process Raman Analyzers

Get to know the product portfolio for Raman spectroscopy from Metrohm Process Analytics

At Metrohm Process Analytics, we understand the importance of accuracy and precision in process analysis. That's why our Process Raman Analyzers undergo rigorous testing and calibration to ensure reliable results every time. Whether you need precise measurements for one or multiple streams, we've got you covered. Explore our cutting-edge Raman systems, including the PTRam Analyzer, 2060 Raman Analyzer, and 2060 RISE, to enhance process analysis capabilities.

Brochure: PTRam Analyzer (8.000.5421, PDF, 572 KB)

Brochure: 2060 Raman Analyzer (8.000.5477, PDF, 2.8 MB)

Brochure: 2060 Raman Intelligent SEnsor «RISE» – Unveiling Insights, Amplifying Precision (8.000.5508, PDF, 2.6 MB)

Regardless of your requirements – We have the perfect Raman Process Analyzer for you

PTRam Analyzer

Compact, rack-mountable Raman analyzer designed for both product and process development. Ideal for analytical labs and pilot plant environments, this single-channel analyzer offers compact efficiency.

2060 Raman Analyzer

A cutting-edge five-channel solution with an integrated reference channel and human interface, meticulously designed for continuous inline process monitoring.

2060 RISE

The 2060 RISE is an inline Raman sensor that allows you to monitor process lines and tanks with ease. Gain immediate access to critical process data with up to 16 sampling points, allowing you to make informed decisions and optimize your process.

Safe and flexible inline monitoring of cell cultures with Raman spectroscopy

By integrating Metrohm Process Analytics Raman Analyzers with SCHOTT ViewPort^® and ViewCell™ sensor interfaces, we offer a comprehensive solution tailored specifically to the biopharmaceutical industry. Our combined solution provides high-quality process performance:

Real-time process monitoring: With the integrated solution of Metrohm Raman Analyzers and SCHOTT’s ViewPort^® optical interfaces, biopharmaceutical companies can monitor crucial parameters inline and in real-time, enabling proactive decision-making and process optimization.

Enhanced biopharma product quality: Our solutions enable the highest level of quality of the pharmaceutical product by providing accurate and reliable monitoring throughout the manufacturing process. This helps minimize the risk of deviations and contributes to compliance with regulatory requirements. Additionally, SCHOTT’s ViewPort® optical interfaces offer highly transmissive optical windows, which enable precise optical signal transmission for better results. The sensor interfaces can be sterilized with the entire bioreactor assembly. The materials used are in accordance with pharma industry best practices.

Sterile and flexible integration: SCHOTT’s sensor interfaces are the only wetted part and maintain the sterile integrity at any point of the cultivation. The optical measurements of the Raman analyzer process instruments from Metrohm can be conducted in-situ while remaining contactless. Using SCHOTT’s PAT components eliminates the need to sterilize the sensor probe. ViewPort® sensor interfaces seamlessly integrate with Metrohm Process Raman Analyzer probes, facilitating probe exchange during operations. The interfaces’ standardized port diameter and connector designs enable fast integration into existing setups. This results in less downtime and optimized productivity.

Comprehensive support: Metrohm Process Analytics is committed to providing comprehensive support to our customers. From initial consultation to installation and ongoing maintenance, our team of experts is dedicated to ensuring the success of your biopharmaceutical processes.

See SCHOTT website for more information

Frequently Asked Questions (FAQ) about Process Raman spectroscopy

Raman spectroscopy, red and green laser on a black background

Raman analyzers use a laser beam to shine on the sample. The Raman scattered light is then collected and sent to the spectrometer. The spectrometer separates the scattered light into different colors, and the detector detects them to create a raman spectrum.

The Raman spectrum shows how light scatters at different wavelengths. It helps identify substances and study molecular interactions by giving information about molecular vibrations.

Learn more about Raman spectroscopy in our blog

Raman spectroscopy offers numerous advantages for process monitoring:

«Real-time» results: It enables instant insights into molecular changes during processes, providing timely feedback for adjustments
Non-destructive analysis: Raman spectroscopy is a non-invasive method that analyzes samples without causing any damage, safeguarding the original state of the monitored substances.
Identification of molecular species: It effectively detects impurities, intermediates, or by-products, supporting with quality assurance and control and ensuring product consistency
Inline process control: Raman spectroscopy allows for direct monitoring of process parameters, allowing for real-time adjustments to maintain desired production conditions.

A Process Raman analyzer is a monitoring system used for real-time analysis of chemical processes. It uses Raman spectroscopy, which uses light to give detailed information about the chemical composition and structure of materials. Various industries utilize these process analyzers to monitor and analyze chemical processes in real-time. Their purpose is to ensure product quality, process efficiency, and compliance with regulations.

In chemical processes, they ensure product quality and process efficiency by tracking reactions. In pharmaceutical manufacturing, they verify drug synthesis processes, detect impurities, and ensure compliance with regulatory standards. Furthermore, they aid in quality control in food and beverage production, polymerization monitoring in polymer production, and pollutant analysis in environmental monitoring efforts.

Learn more in our application notes for Process Raman spectroscopy