Applikationer
- AN-K-047Determination of the water content in transformer oil with 885 Compact Oven Sample Changer and 899 Coulometer
This Application Note describes the determination of the water content in transformer oil using the oven technique.
- AN-K-048Sample preparation with the oven technique – relative blank
Large sample sizes can lead to subtraction of too high blank values. This Application Note describes the calculation of a relative blank and thus helps to improve the accuracy of the method.
- AN-K-049Water in plastic pellets – Interference-free determination based on ASTM D6869
The water content, also called moisture content, of plastics is an important quality parameter, as it affects the properties and processability of some plastics. A high water content can lead to degradation of the plastic by hydrolysis or cause surface imperfections. Additionally, it can affect the physical properties of some plastics.For this analysis, the oven technique is used, as volatile compounds present in plastics will interfere, if the water content is directly determined by coulometric Karl Fischer titration. The water content determination in polycarbonate pellets, performed with the 885 Compact Oven Sample Changer and 899 Coulometer, is described in this Application Note.
- AN-K-050Determination of the water content in gelatine with the 885 Compact Oven Sample Changer and the 899 Coulometer
This Application Note describes the determination of the water content in gelatine using the oven technique.
- AN-K-051Determination of the water content in spirits with MATi 10
This Application Note describes the automated determination of the water content in liqueur (30% v/v) using volumetric Karl Fischer titration (MATi 10).
- AN-K-052Determination of the water content in sodium acetate with MATi 10
In this application note, Karl Fischer titration is used to determine water content in sodium acetate trihydrate. The MATi 10 allows this determination to be automated, saving users time in the laboratory.
- AN-K-053Determination of the water content in toothpaste with MATi 10
This Application Note describes the automated determination of the water content in toothpaste using volumetric Karl Fischer titration (MATi 10).
- AN-K-054Determination of the water content in tablets
This Application Note describes the determination of the water content in tablets using automated volumetric titration including sample preparation (MATi 11).
- AN-K-067Determination of the bromine index of aromatic hydrocarbons by coulometric titration according to ASTM D1492
The bromine index indicates the degree of unsaturation and relies on the simple addition of bromine to the double bond of alkenes. One mole of bromine is consumed for each mol of carbon-carbon double bond. The bromine index indicates the olefin content in aromatic hydrocarbons. This Application Note describes the determination by coulometric titration according to ASTM D1492.
- AN-K-068Water content determination and acid-base titration in parallel
The water content determination by volumetric Karl Fischer titration is one of the most important analyses worldwide. Using an OMNIS system consisting of an OMNIS Titrator and an OMNIS Sample Robot, the fully automatic analysis of water content is possible in various products and matrices. The OMNIS Sample Robot is capable of running several different titrations in parallel. In this Application Note, we present the results of a volumetric Karl Fischer titration run in parallel to an aqueous acid-base titration on the same system. The water content is not influenced by the parallel running aqueous titration, allowing the combination of potentiometric titrations and Karl Fischer titrations on the same automated system.
- AN-K-069Water in E-liquids – Fully automatic determination by volumetric Karl Fischer titration
The vaping and electronic cigarette industries are growing. The mixtures used in these products are usually called e-liquid, e-fluid, or e-juice. Toensure the quality of these e-liquids, testing the most important parameters is required. One important quality control parameter is water or moisture content.Water/moisture content determination by Karl Fischer titration (KFT) is an established and reliable procedure. Compared to other methods the advantages of KFT are its accuracy, speed, and selectivity. For high water content samples, such as e-liquids, volumetric KFT is the method of choice.In this Application Note a system for the fast and reliable determination of the water content in E-liquids is presented. This fully automated system performs the analysis including system preparation, blank, titer, and sample determination completely unattended. Hence, the workload of the operator is reduced to only weighing in the sample and placing the sealed sample vessels on the system.
- AN-K-070Water in petroleum products
Moisture in petroleum products causes several issues: corrosion and wear in pipelines and storage tanks, an increase in debris load resulting in diminished lubrication, blocked filters, or even harmful bacterial growth. As a result, increased water content can lead to infrastructure damage, higher maintenance costs, or even unwanted downtimes.Coulometric Karl Fischer titration is the method of choice for low water content in petroleum products. Using a Karl Fischer oven to vaporize the water present in the sample prior to titration not only greatly reduces matrix interferences, it can also be fully automated. This allows a reliable and cost-efficient analysis of the water content according to ASTM D6304 (Procedure B) in products such as diesel, hydraulic oil, lubricant, additive, turbine oil, and base oil.
- AN-K-071Water content in flour, dough, and bread
Water content determination by volumetric Karl Fischer titration is one of the most important analyses worldwide, particularly when it comes to food quality. This parameter has a major influence on the growth of microorganisms, and thus indirectly affects the storability of the raw materials and final products. Consistent quality is only possible with precise measurements during the process. This measurement is performed with the Metrohm Eco KF Titrator for flour, dough, and baked goods.
- AN-K-07234433 HYDRANAL™ NEXTGEN Coulomat AG-FI
Karl Fischer reagents contain buffer substances (usually imidazole) since the reaction constant is dependent on the pH value. A constant pH therefore ensures the most repeatable results. In 2015, imidazole was classified by European Union the as a CMR (carcinogenic, mutagenic or toxic) substance and the statement H360D was added, stating possible harm to fertility or a fetus. Meanwhile, other reagents free of imidazole are available for purchase. This Application Note summarizes test measurements with 34433 HYDRANAL™ NEXTGEN Coulomat AG-FI.
- AN-K-073Volumetric Karl Fischer titration with Scharlau Aquagent® reagents
Test measurements on water standards are performed with an OMNIS KF Titrator and Karl Fischer reagents Aquagent® Complet 5 and Methanol Fast from Scharlau.
- AN-K-074Water content in crude oil determined with Karl Fischer titration
To determine water in crude oil, ASTM D4928 recommends coulometric Karl Fischer titration with the oven method, allowing full automation for high reproducibility.
- AN-M-001Aliphatic monocarboxylic acids in produced water using IC/MS coupling
Determination of acetic, propionic, butyric, valeric, and caproic acid in produced water using anion chromatography with conductivity and MS detection after post-column addition of ammonia for MS detection and inline sample preparation by dialysis.
- AN-M-002Chlorite, chlorate, and perchlorate in explosion residue using IC/MS coupling
Determination of chlorite, chlorate, and perchlorate in explosion residue using anion chromatography with conductivity and MS detection in tandem.
- AN-M-003Phosphate in produced water using IC/MS coupling after sample preparation by inline dialysis
Determination of phosphate in produced water containing up to 100 g/L chloride as well as crude oil using anion chromatography with conductivity and MS detection after inline dialysis.
- AN-M-004Traces of bromide and bromate in drinking water by IC-MS, determination of the Method Detection Limit (MDL)
Determination of bromide and bromate in drinking water using anion chromatography with MS detection.
- AN-M-005Traces of diethylamine and triethylamine by IC MS
Determination of diethylamine and trimethylamine using cation chromatography with MS detection.
- AN-M-007Determination of urea in ultrapure water using IC-MS
Urea is not a typical analyte for ion chromatography. In combination with MS, however, IC is the method of choice for the trace analysis of urea in ultrapure water. This Application Note shows the determination of urea concentrations in the ppb range using the Metrosep C 6 - 250/4.0 column.
- AN-M-008Determination of chromate in water using IC-ICP/MS detection
Hexavalent chromium, also referred to as chromate or Cr(VI), is considered toxic and potentially carcinogenic, which is why its concentrations in drinking water should be kept as low as possible. Determination of Cr(VI) is performed by combining ion chromatography with ICP/MS. Separation takes place on the Metrosep A Supp 1 Guard/4.6.
- AN-M-009Determination of chromium(VI) in migration solution from toys via IC-ICP/MS
Chromate (Cr(VI)) is considered toxic and potentially carcinogenic, which is why its concentrations in children's toys should be kept as low as possible. The EU directive 2009/48/EC defines limit values for the migration of chromate from children's toys. The hydrochloric-acid-containing migration solution is diluted with a buffer. 2000 μL of this solution are injected automatically using intelligent preconcentration technology and matrix elimination. Detection takes place via ICP/MS.
- AN-M-010Speciation analysis of arsenic and selenium in drinking water using IC-ICP/MS
The maximum contaminant concentrations (Maximal Contaminant Level, MCL) of inorganic arsenic and selenium species in drinking water should not exceed 10 and 50 µg/L, respectively. Given that each of the two elements occurs in two oxidation levels – trivalent and pentavalent – a separation step is necessary prior to ICP/MS detection. This Application Note shows the simultaneous determination of the two arsenic (arsenite and arsenate) and selenium species (selenite and selenate). Separation takes place on the Metrosep Dual 3 - 100/4.0 column.
- AN-M-011The determination of soluble Cr(lll) and Cr(VI) in alkali soil extract using IC-ICP/MS
As a rule, soil contains small percentages of chromium that originate chiefly from rock weathering processes, although anthropogenic sources also exist. The speciation analysis of trivalent – Cr(III) – and hexavalent chromium – Cr(VI) – is important, because the former is a trace element and the latter is highly toxic. The two chromium species are separated as Cr(III)-EDTA-complex and chromate on the Metrosep A Supp 4 - 250/4.0 column. Mass spectrometric isotope dilution analysis (SIDMS) is used for quantification.
- AN-M-012Iron speciation analysis in soil using IC-ICP/MS in accordance with EPA SW846 Method 6800
Speciation analysis of iron is important, given that its oxidation level has a great influence on environmental response, not only with respect to its absorption by organisms but also to the transport and the storage of the element. Iron(II) and Iron(III) are separated on the Metrosep A Supp 10 S-Guard/4.0 column. IC-ICP/MS with isotope dilution is used for quantification.
- AN-M-013Chromium speciation by IC-ICP-MS
Differentiation between Cr(III) and Cr(VI) is possible following ISO 24384 guidelines by combining ion chromatography with inductively coupled plasma mass spectrometry.
- AN-M-014Trace perchlorate in drinking water – Determination as per US EPA 332.0 applying IC-MS/MS
Perchlorate contamination in drinking water may have different sources. Besides natural deposits, anthropogenic sources like fertilizers and rocket fuel residue add to hazardous water contamination. Perchlorate interferes with iodine uptake into the thyroid gland. Newborns and children are particularly vulnerable, affected as thyroid hormones are essential for growth. Besides ion chromatography (IC) followed conductivity detection, IC hyphenated with an MS detector can be used to measure perchlorate down to sub-µg/L levels. In this application IC is hyphenated with a triple-quadrupole MS (IC-MS/MS) for perchlorate determination in order to meet the requirements of EPA 332.0. This IC-MS/MS setup avoids the possible interference of sulfate.
- AN-M-015Trace haloacetic acids, dalapon, and bromate measurement in drinking water
Chlorinating drinking water can form carcinogenic byproducts. EPA Method 557 enables µg/L-level quantification of haloacetic acids using Metrohm IC-MS/MS technology.
- AN-M-016Resolving haloacetic acids in water
During drinking water disinfection with chlorine, chloramine, or ozone, potentially toxic halogenated byproducts can be formed. The disinfectants can react with naturally occurring bromide and/or organic matter in the source water and form one of the most common and highly toxic disinfection byproducts (DBPs): haloacetic acids (HAAs). To protect human health, maximum tolerable levels of HAA in drinking waters are regulated (EPA 816-F-09-004). The EPA Method 557 specifies the analysis of HAAs beside bromate and dalapon by ion chromatography coupled to tandem mass spectroscopy (IC-MS/MS) with LODs varying from 0.02–0.11 µg/L. However, even with single MS, a high sensitivity is achieved to determine the current MCLs within an adequate accuracy. This Application Note describes the analysis of bromate, chlorite, monochloroacetic acid (MCAA), monobromoacetic acid (MBAA), bromochloroacetic acid (BCAA), bromodichloroacetic acid (BDCAA), dibromoacetic acid (DBAA), dichloroacetic acid (DCAA), tribromoacetic acid (TBAA), chlorodibromoacetic acid (CDBAA), and trichloroacetic acid (TCAA) with IC/MS. The Metrohm Driver 2.1 for EmpowerTM offers the analysis as a single software solution with EmpowerTM.
- AN-M-017IC-MS/MS analysis of trifluoroacetic acid according to DIN 38407-53
The new DIN draft standard 38407-53 outlines TFA analysis in water using direct injection LC-MS/MS, enabling quantification from 0.1–3.0 μg/L as shown in this Application Note.
- AN-N-001Nitrate and perchlorate in hydrochloric acid eluate
Determination of NO3- and ClO4- in the presence of a large excess of HCl using anion chromatography with direct conductivity detection (using time program for full scale change after 18 min).
- AN-N-002Determination of methylarsonic acid and dimethylarsinic acid
Determination of methylarsonic acid and dimethylarsinic acid using anion chromatography with direct conductivity detection.
- AN-N-003Five anions in solder paste
Determination of anions in solder paste after alcoholic extraction using anion chromatography with direct conductivity detection.
- AN-N-004Fluoride, chloride, bromide, nitrate, and sulfate in organic substances after Schoeniger combustion
Determination of anions in a Schoeniger absorption solution of a test mixture without decomposition of the H2O2 using anion chromatography with direct conductivity detection.
- AN-N-005Traces of silica (SiO2) in water (e.g., boiler water) after preconcentration
Determination of silica (as silicate) in pure water with preconcentration using anion chromatography with direct conductivity detection (without any post-column reaction).
- AN-N-006Chloride, nitrate, phosphate, sulfate, and oxalate in dried potatoes
Determination of chloride, nitrate, phosphate, sulfate, and oxalate in dried potatoes using anion chromatography with direct conductometric detection.
- AN-N-007Acetate and methanesulfonate in an organic disodium salt
Determination of acetate and methansulfonate in an organic salt using anion chromatography with direct conductivity detection.
- AN-N-008Five anions in an organic solvent (toluene)
Determination of acetate, formate, chloride, bromide, and sulfate in toluene using anion chromatography with direct conductivity detection.
- AN-N-009Carbonate in an amine solution
Determination of carbonate in a solution of methyl-monoethanol-amine with anion chromatography with direct conductivity detection.
- AN-N-010Chloride, nitrate, phosphate, and sulfate in plant leaf extracts
Determination of chloride, nitrate, phosphate and sulfate in plant leaf extracts using anion chromatography with direct conductometric detection.
- AN-N-011Chloride, bromide, and iodide in alkaline combustion solutions
Determination of chloride, bromide, and iodide in alkaline combustion solutions using anion chromatography with direct conductivity detection.
- AN-N-012Acetate, lactate, and chloride in electrolyte solutions
Determination of acetate, lactate, and chloride in electrolyte solutions using anion chromatography with direct conductivity detection.
- AN-N-013Chloride, nitrate, and sulfate in sugar-containing solutions
Determination of chloride, nitrate, and sulphate in sugar-containing solutions without matrix elimination using anion chromatography with direct conductometric detection.
- AN-N-014Five anions in effluent water
Determination of fluoride, chloride, nitrite, nitrate, and sulfate in an effluent sample using anion chromatography with direct conductometric detetction.
- AN-N-015Determination of pyrophosphate, tripolyphosphate, and trimetaphosphate
Determination of pyrophosphate, tripolyphosphate, and trimetaphosphate using anion chromatography with direct conductivity detection.
- AN-N-022Traces of iodide in hydrochloric acid (25%) using amperometric detection
Determination of traces of iodide in HCl (25%) using anion chromatography with amperometric detection at a silver electrode.
- AN-N-024Traces of carbonate in urea
Determination of traces of carbonate in urea using anion chromatography with direct conductivity detection.
- AN-N-025Traces of nitrite, thiosulfate, and iodide using amperometric detection
Determination of traces of nitrite, thiosulfate, and iodide using anion chromatography with amperometric detection at the carbon paste electrode.
- AN-N-027Traces of bromide and iodide using amperometric detection
Determination of traces of bromide and iodide using anion chromatography with amperometric detection at the silver electrode.
- AN-N-028Traces of bromide in hydrochloric acid (32%) using amperometric detection
Determination of traces of bromide in HCl (32%) using anion chromatography with amperometric detection at the silver electrode.
- AN-N-030Nitrate, sulfate, and thiocyanate in additives for building materials
Determination of nitrate, sulfate, and thiocyanate in additives for building materials using anion chromatography with direct conductometric detection.
- AN-N-033Fluoride and chloride in gypsum
Determination of fluoride and chloride in gypsum using anion chromatography and subsequent direct conductometric detection.
- AN-N-034Sulfate in gypsum
Determination of sulfate in hydrochloric acid digest of gypsum using anion chromatography with direct conductometric detection.
- AN-N-037Perchlorate in process water
Determination of perchlorate in process water using anion chromatography with direct conductivity detection.
- AN-N-038Traces of iodide in acetic acid using amperometric detection
Determination of traces of iodide in acetic acid using anion chromatography with amperometric detection at the carbon paste electrode.
- AN-N-039Iodide in wastewater (dye industry) using dialysis for sample preparation
Determination of iodide in wastewater (dye industry) using anion chromatography with amperometric detection at the silver electrode and dialysis for sample preparation.
- AN-N-040Cyanide in a standard solution using the Metrosep A Supp 1 - 250/4.6 column
Determination of cyanide using anion chromatography with amperometric detection at the silver electrode.
- AN-N-044Silicate in tap water
Determination of silicate in tap water using anion chromatography with direct conductivity detection.
- AN-N-045Chromate using post-column reaction
Determination of chromate using anion chromatography with post-column reaction and UV/VIS detection.
- AN-N-046Determination of fosetyl-aluminum by non-suppressed ion chromatography
Determination of fosetyl-aluminum (aluminum tris(o-ethylphosphate)) using anion chromatography with direct conductivity detection.
- AN-N-048Carbonate in washing powder
Determination of carbonate in washing powder using anion chromatography with direct conductivity detection.
- AN-N-049Borate and silicate in washing powder
Determination of borate and silicate in washing powder using anion chromatography with direct conductivity detection.
- AN-N-051Acetate, chloride, citrate, and sulfate in a concentrate of an infusion solution containing amino acids and dipeptides
Determination of acetate, chloride, citrate, and sulfate in a concentrate of an infusion solution using anion chromatography with direct conductivity detection. Non-suppressed IC is used to avoid interferences by the amino acids.
- AN-N-054Borate and silicate in ultrapure water
Determination of borate and silicate in ultrapure water using anion chromatography with direct conductivity detection.
- AN-N-057Chloride and sulfate in a reactive dye
Determination of chloride and sulfate in a reactive dye using anion chromatography with direct conductivity detection. Suppressed IC does not work as the dye is hydrolyzed in alkaline solution and releases sulfate.
- AN-N-058LOD and LOQ for silicate and borate determination according to EPA (MDL procedure)
Determination of silicate and borate and their limits of determination (LOD) and quantification (LOQ) according to the EPA procedure for method detection limit (MDL) using anion chromatography with direct conductivity detection and Metrohm Inline Calibration.
- AN-N-061Acetate, chloride, and malate in infusion solutions
Determination of acetate, chloride, and malate in an infusion solution using anion chromatography with direct conductivity detection.
- AN-N-062Acetate, phosphate, chloride, and citrate in infusion solutions
Determination of acetate, phosphate, chloride, and citrate in an infusion solution using anion chromatography with direct conductivity detection.
- AN-N-063Nitrate in a nickel plating bath
Determination of nitrate in a nickel plating bath using anion chromatography with UV/VIS detection (205 nm).
- AN-N-064Sodium dodecylsulfate (SDS) in water
Determination of sodium dodecylsulfate (SDS, sodium laurylsulfate) using anion chromatography with direct conductivity detection.
- AN-N-065Borate in borate effluent
Determination of borate in a borate effluent using anion chromatography with direct conductivity detection.
- AN-N-066Four phenols in tap water using amperometric detection
Determination of phenol, m-cresol, 2,6-dimethylphenol and 2,3,6-trimethylphenol in tap water with amperometric detection using a glassy carbon electrode.
- AN-N-069Chloride and sulfate in an emulsion using Metrohm Inline Dialysis
Determination of chloride and sulfate in effluent after Metrohm Inline Dialysis using anion chromatography with direct conductivity detection.
- AN-N-070Sulfide in effluent
Determination of sulfide in an effluent sample using anion chromatography with amperometric detection.
- AN-N-071Alendronate in tablets in accordance with the Chinese Pharmacopoeia
Alendronate, also referred to as alendronic acid, is a biphosphonate used to treat osteoporosis. It is the main ingredient in the tablets and is determined in accordance with the Chinese Pharmacopoeia (2015). Separation takes place in the Metrosep A Supp 4 - 250/4.0 column; direct conductivity detection is used for quantification.
- AN-N-073Trace analysis of iodide in sodium chloride applying amperometric detection
Pure sodium chloride contains much less iodide than e.g., table salt which usually is fortified with it. Trace determination of iodide is easily performed applying ion chromatography with amperometric detection. This detection mode is particularly selective and sensitive. The actual separation is achieved using a Metrosep A Supp 5 - 250/4.0 column. The detection happens at a silver working electrode. LOQ is at approximately 1.0 μg/L (in solution) and 50 μg/kg in the sample. The use of a shorter column might further improve the LOQ.
- AN-NIR-001Determination of active ingredients in solid (pharmaceutical) dosage forms utilizing solid-state standard additions
Two of the leading pain remedies, aspirin and acetaminophen, are compared with generic samples for content uniformity testing using near-infrared spectroscopy (NIRS). The method of standard addition is used for quantification. To reduce most of the effects that stem from particle size and packing differences, second derivative spectra are used.
- AN-NIR-002Nondestructive, single tablet analysis using the NIRS XDS RapidContent Analyzer
This Application Note shows the potential of NIRS as a rapid (< 30 s) and nondestructive screening tool for solid dosage forms (e.g. tablets). NIRS requires neither sample preparation nor solvent use. Interferences that derive from scattering are minimized by converting to second derivative spectra.
- AN-NIR-003Analysis of copolymer levels in polymer pellets by near-infrared spectroscopy
This Application Note describes the determination of copolymer levels in polyethylene (PE) and polyvinylacetate (PVA) pellets using NIRS. The determination of the composition of the polymer blends takes less than 30 seconds and requires no sample preparation. The second derivative spectra are analyzed by means of the linear least-squares regression method.
- AN-NIR-004Determination of additives in polymer pellets by near-infrared spectroscopy
This Application Note shows that NIR spectroscopy is an excellent tool for determining low concentrations of additives in finished polypropylene pellets. This is demonstrated by monitoring the UV stabilizer Tinuvin 770 and the antioxidant Irganox 225. The application of multiple linear regression (MLR) models minimizes interferences that originate from different coating thicknesses and interferences in the polymer pellets.
- AN-NIR-005Determination of coatings on nylon fibers by near-infrared spectroscopy
This Application Note demonstrates how NIR spectroscopy can be used to determine the content of coatings on nylon fibers, quickly and without requiring either sample preparation or the use of reagents. In order to suppress the effects arising from scattering on the surface coatings, one forms the second derivative spectra; the linear least-squares regression method is used to calculate the calibration function.
- AN-NIR-008Determination of lignin in wood pulp
This Application Note describes how NIR spectroscopy can be used to determine residual lignin content in wood pulp. Using the major absorbance peaks of both lignin and cellulose in the second derivative spectra, the residual lignin content in wood pulp can be monitored during paper production.
- AN-NIR-009Determination of hardwood/softwood content in wood products by near-infrared spectroscopy
Near-infrared spectroscopy (NIRS) is ideally suited to monitor the hardwood and softwood content in pulp and paper products.The herein described method bases on the fact that the changes in hardwood and softwood content are reflected in the intensity of the absorption bands of cellulose. A linear least-squares regression on second derivative spectra provide results that correspond very well with those of conventional laboratory determinations. With NIRS, an analytic method is available that provides results in real time.
- AN-NIR-010Process monitoring in a butyl acetate production stream using near-infrared spectroscopy
This Application Note describes an NIR method for monitoring the esterification process in butyl acetate production. The developed NIR method shows excellent analytical performance equivalent to that obtainable with more time-consuming GC methods.
- AN-NIR-011Transferability of a calibration model for caffeine on the NIRS XDS Rapid Content Analyzer
This Application Note demonstrates that a calibration model for caffeine and microcrystalline cellulose developed on the NIRS XDS Rapid Content Analyzer (RCA) is transferable to other NIRS XDS RCA. Due to the improved signal-to-noise ratio, reduced bandwidth and improved wavelength precision of the NIRS XDS, the transferability of the calibration model can be easily and efficiently performed.
- AN-NIR-012Increase the accuracy of your NIR measurements with instrument calibration
This Application Note describes how the accuracy of your NIR measurements can be increased with instrument calibration.
- AN-NIR-013Increase the accuracy of your NIR measurements with reference standards
This Application Note describes how the accuracy of your NIR measurements can be increased with reference standards.
- AN-NIR-014Following the progress of pharmaceutical mixing studies using near-infrared spectroscopy
Well-mixed active substances for medications are indispensable in the pharmaceutical industry. This applies not only to the pharmaceutical active ingredient but also for lubricants, binding agents, explosives, oxidants and dyes. Analysis of these active ingredients is expensive; they are also only rarely analyzed as a rule. The progress of the mixing procedures can be followed conveniently with NIR spectroscopy, on the one hand using visual comparisons and on the other by means of spectral algorithms. The progress of mixing processes can be predicted in real time with the help of the spectrum when the latter is used.
- AN-NIR-016Near-infrared spectroscopy for monitoring a single-pot granulator
This Application Note describes the utilization possibilities of a new sensor design that permits, in combination with an NIRS XDS Process Analyzer, the determination of solvent residues in a High-Shear Granulator during the drying phase. This system configuration reduces the scattering of the density distribution of the powder samples so that it is possible, directly in the process, to model the water and solvent content precisely.
- AN-NIR-017NIR "predictive model" for the release of pharmaceutical active ingredients from solid dosage forms
This Application Note shows that NIR "predictive models" are optimally suitable for the non-destructive measurement of the release profiles of active ingredients from tablets. This is in accordance with the Process Analytical Technology (PAT) initiative of the FDA. The results demonstrate how NIRS considerably reduces the work involved for release studies in the laboratory.
- AN-NIR-019Human stool analysis by near-infrared spectroscopy
This Application describes the determination of moisture, nitrogen, and fat in stool samples using near-infrared spectroscopy. These parameters are of great importance in medical diagnostics.
- AN-NIR-020Determination of the water content of soft contact lenses
The determination of the water content of soft contact lenses using NIR spectroscopy is described in this Application. A liquid sample kit with gold diffuse reflector was used for measuring the lenses in transflexion mode. A PLS model was developed for predicting the water content.
- AN-NIR-021Monitoring the purity of recovered solvents with NIRS
The purity of a recovered solvent (dichlormethane/methylene chloride) and two of its most important contaminants (methanol and water) are monitored with NIR spectroscopy.
- AN-NIR-022Quality Control of Gasoline
In recent years, there has been a significant push to reduce the environmental impacts of fuels through improvements to fuel quality. The determination of key quality parameters of gasoline, namely research octane number (RON, ASTM D2699-19), motor octane number (MON, ASTM D2700-19), anti knock index (AKI), aromatic content (ASTM D5769-15), and density, conventionally requires several different analytical methods, which are laborious and need trained personnel. This application note demonstrates that the XDS RapidLiquid Analyzer, operating in the visible and near-infrared spectral region (Vis-NIR), provides a cost-efficient and fast solution for the multiparameter analysis of gasoline.
- AN-NIR-023Quality Control of PET
Determination of the diethylene glycol content, isophthalic acid content, intrinsic viscosity (ASTM D4603), and the acid number (AN) of polyethylene terephthalate (PET) is a lengthy and challenging process due to the sample’s limited solubility and the need to use different analytical methods. This application note demonstrates that the DS2500 Solid Analyzer operating in the visible and near-infrared spectral region (Vis-NIR) provides a cost-efficient and fast solution for a simultaneous determination of these parameters in PET. Vis-NIR spectroscopy allows for the analysis of PET in less than one minute without sample preparation or using any chemical reagents.
- AN-NIR-024Quality control of pyrolysis gasoline
Pyrolysis gasoline (Pygas) is a by-product of ethylene production, which contains unwanted conjugated diolefins making it unsuitable as a motor fuel. To overcome this limitation, the olefin content needs to be reduced below 2 mg/g pygas in a selective hydrogenation unit (SHU). The diene value, or maleic anhydride value (MAV), is usually determined by the lengthy Diels-Alder wet chemical method (UOP326-17), requiring highly trained analysts. In contrast to the primary method, near-infrared spectroscopy (NIRS) is a cost-efficient and fast analytic solution for the determination of diene value in pyrolysis gasoline.
- AN-NIR-025Real-time inline predictions of jet fuel properties by NIRS
This Application Note describes the determination of various indices (mainly with ASTM and ISO conformance) for the characterization of kerosene as aviation turbine fuel using near-infrared spectroscopy. The following parameters were determined with the aid of an NIRS XDS Process Analyzer: degree of density in accordance with the American Petroleum Institute (API), aromatics content, Cetane Index, distillation characteristics pursuant to ASTM D86, flash point, freezing point, viscosity and hydrogen content. All of these parameters are determined quickly and easily with just a single measurement.
- AN-NIR-026Dye, diethylene glycol, water and surfactant content in ink
Ink is a complex mixture that, along with numerous additives, is comprised mainly of solvent, dye, water and surfactant. Vis-NIR spectroscopy is outstandingly suitable for providing rapid and reliable determinations of constituents in the context of quality controls. This Application Note describes the determination of diethylene glycol (DEG), water, dye and surfactant.
- AN-NIR-027Identification of 46 medicinal and aromatic plants for the cosmetics and pharmaceuticals industry
This Application Note shows how, with the help of Vis-NIR spectroscopy and a special plant library, 46 different medicinal and aromatic plants, e.g., Organicum majoricum and Tilia cordata, can be conveniently identified on the basis of their spectrum. In comparison with alternative methods for the determination of plants, which are elaborate and require experienced scientists for their performance, the Vis-NIR method permits rapid and uncomplicated identification.
- AN-NIR-028Data and method transfer from System II analyzer to Metrohm NIRS XDS or DS2500 analyzer
This Application Note shows the transfer of near-infrared spectroscopy analysis methods from the FOSS NIRSystems System II (5000/6500) Analyzer to the Metrohm NIRS XDS und DS2500 Analyzers. In addition, the advantages of the new NIRS XDS and DS2500 analyzers with extended spectral range and improved resolution are displayed, in particular with respect to the FOSS NIRSystems System II analyzer.
- AN-NIR-029Butyl glycol and propylheptyl alcohol in water-borne paint
This Application Note shows the determination of two important additives – butylglycol and propylheptyl alcohol – in water-soluble lacquers using Vis-NIR spectroscopy. Other lacquer constituents can also be determined in addition to the two additives.
- AN-NIR-030Determination of amine number and solid content of dipping paint
This Application Note shows how the amine number and the solids content in electrophoretic lacquer coatings can be determined quickly and simply with Vis-NIR spectroscopy. Additional parameters can be determined reliably and conveniently with a single measurement.
- AN-NIR-031Purity, degree of substitution and water content of carboxymethyl celluloses
This Application Note shows how purity, degree of substitution and water content of carboxymethyl celluloses (CMC) can be determined conveniently and rapidly in a single measurement with Vis-NIR spectroscopy.
- AN-NIR-032Determination of the cotton linter and pulp content in cellulose
This Application Note shows the determination of the ratio of cotton linter to pulp in cellulose samples with Vis-NIR spectroscopy. This linter-pulp ratio is an important characteristic in the paper industry which, unlike with elaborate wet-chemistry methods, can be determined quickly and conveniently with Vis-NIR spectroscopy.
- AN-NIR-033Cobalt content, solids content, specific weight and viscosity in cobalt octoate
This Application Note describes the simultaneous determination of the four most important analysis parameters of paint dryers – cobalt and solids contents, specific weight and viscosity – using a VIS-NIR analyzer. The visible range correlates with the metal content, while the NIR region provides the specific weight, viscosity and solids content.
- AN-NIR-034Analysis of polymer granulate using near-infrared spectroscopy
This Application Note shows that near-infrared spectroscopy with its exceptionally short analysis times significantly accelerates quality monitoring of polymer granulates and raw materials. Polyethylene (PE) und polypropylene (PP) can be identified in parallel. PE density is also determined in the same measurement.
- AN-NIR-035Quality Control of Polyols
Toxic and corrosive chemicals such as p-toluenesulfonyl isocyanate (TSI) and tetrabutylammonium hydroxide are used for the Hydroxyl Number analysis of polyols by titration according to ASTM D4274-16. This application note demonstrates how the XDS RapidLiquid Analyzer operating in the visible and near-infrared spectral region (Vis-NIR) provides a cost-efficient and fast solution for the determination of the hydroxyl (OH) number of polyols. With no sample preparation or chemicals needed, Vis-NIR spectroscopy allows for the analysis of polyols in less than a minute.
- AN-NIR-036Moisture content and pH value in crude tall oil (CTO)
This Application Note shows the fast and parallel determination of water content and pH value in crude tall oil samples using near-infrared spectroscopy (NIRS). Crude tall oil is an important byproduct of pulp production in the power process. NIRS is an efficient alternative to conventional laboratory methods: It permits rapid raw material inspection, process monitoring and final product checking.
- AN-NIR-037Determination of polymorphous sulfathiazoles by near-infrared spectroscopy (NIRS)
Sulfathiazoles are sulfonamides with antibiotic effect that occur in various polymorphous forms and that are often used in veterinary medicine. This Application Note shows the differentiation between commercial and sulfathiazole form I using near-infrared spectroscopy (NIRS) with the help of the overtone frequencies of N-H stretching vibration. Form I is the least stable polymorphous form. Crystallization and polymorphism must be monitored as part of quality controls. In this, NIRS is considerably more rapid and more reliable than conventional laboratory methods.
- AN-NIR-039Multi-parameter analysis of wood pulp using Vis-NIR spectroscopy
In this Application Note, Vis-NIR spectroscopy (Vis-NIRS) is used to determine six wood pulp properties in a single measurement: kappa number, applied density, freeness, breaking strength, buckling strength and tensile strength.
- AN-NIR-040Protein content in dietary supplements and near-infrared spectroscopy (NIRS)
This Application Note describes the quantification of protein content in dietary supplements using Vis-NIR spectroscopy to reduce the workload of time-consuming and waste-generating primary methods, such as Kjeldahl digestion.
- AN-NIR-041Multiparameter Quality Control of Lubricants with NIRS
For lubricant analysis, determination of the Acid Number (ASTM D664), viscosity (ASTM D445), moisture content (ASTM D6304), and color number (ASTM D1500) require the use of multiple analytical technologies and, in part, large volumes of chemicals. This application note demonstrates that the XDS RapidLiquid Analyzer operating in the visible and near-infrared spectral region (Vis-NIR) provides a fast and cost-efficient alternative for the determination of the AN, viscosity, moisture content, and color number of lubricants. With no sample preparation or chemicals needed, Vis-NIR spectroscopy allows for multi parameter analysis of lubricants in less than one minute.
- AN-NIR-042Quantification of USP heparin units using near-infrared spectroscopy
Heparin acts as an efficient anticoagulant and, in addition to direct injection, is also used as a lock-flush solution for rinsing catheters. Vis-NIR spectroscopy can be used to determine the strength of contaminated and purified heparin. This Application Note demonstrates that heparin strength can be determined reliably with Vis-NIR spectroscopy.
- AN-NIR-043Analytical data transfer between a Fourier transform and a dispersive NIR instrument
This Application Note demonstrates the data transfer from a Fourier transform to a dispersive NIR instrument, using quality control of lubricating oils as an example application. It is shown that FT-NIR instruments can be replaced by dispersive ones without time-consuming sample remeasurement and subsequent method development.
- AN-NIR-044Multiparameter Quality Control of Palm Oil with NIR Spectroscopy
Determination of key quality parameters of palm oil, namely free fatty acids (FFA), iodine value (IV), moisture content, deterioration of bleachability index (DOBI), and carotene require the use of several different analytical methods, which are laborious and can lack in accuracy. This application note demonstrates that the XDS RapidLiquid Analyzer operating in the visible and near infrared spectral region (Vis-NIR) provides a cost-efficient and fast solution for the determination of these quality control parameters in palm oil. With no sample preparation or chemicals needed, Vis-NIR spectroscopy allows for the analysis of palm oil in less than a minute and can be used by anyone.
- AN-NIR-046Qualification of droplet morphology in hair conditioner by Vis-NIR spectroscopy
Vis-NIR spectroscopy is used to determine the droplet morphology in hair conditioner. This Application Note shows that near-infrared (NIR) spectroscopy can be used to distinguish between unprocessed and processed hair conditioner and to qualify quality parameters such as the droplet size.
- AN-NIR-047Quality control of an active ingredient in hair creams using near-infrared spectroscopy
Visible Near-infrared (Vis-NIR) spectroscopy is a valuable chemical analysis tool that can be used to determine quality parameters of hair creams. A qualitative method was developed in order to allow a fast out-of-spec analyses of an active antibacterial ingredient.
- AN-NIR-048Quality control of an active ingredient in hair spray using near-infrared spectroscopy
Near-infrared spectroscopy (NIRS) was used as an analysis method for quality control of hair spray samples. A model for an active ingredient within hair sprays was developed, enabling fast and reliable out-of-specification analyses.
- AN-NIR-049Quantification of TAED, PCS and protease enzyme in detergents using Near-infrared spectroscopy
Visible near-infrared (Vis-NIR) spectroscopy can be used as a fast and accurate analytical method for the quantification of different analytes and active ingredients in detergents, such as tetraacetylethylendiamin (TAED), sodium percarbonate (PCS), and enzymes. This Application Note shows how NIRS can be used for multi-constituent analyses in detergents in a single measurement.
- AN-NIR-050Quantification of active ingredients in shampoo using near-infrared spectroscopy (NIR)
Near-infrared spectroscopy (NIRS) was used in a preliminary study as a fast and accurate method for the quantification of different preservatives and active ingredients in liquid shampoo. This Application Note shows how this analytical method allows the simultaneous determination of several constituents in shampoo in a single measurement.
- AN-NIR-051Simultaneous determination of Total Fatty Matter, Iodine Value, and C8–C14 in soap noodles by Vis-NIRS
Near-infrared spectroscopy (NIRS) was used as an analysis method for quality control of soap noodles. Quantitative models for the determination of Total Fatty Matter, Iodine Number, and C8–C14 were developed, enabling fast and reliable quality control.
- AN-NIR-052Simultaneous determination of xanthan gum, optical density, and glucose in aqueous solutions by Vis-NIRS
Near-infrared spectroscopy (NIRS) was used as an analysis method for quality control of aqueous xanthan gum solutions. Quantitative models for the determination of optical density, glucose, and xanthan gum were developed, enabling fast and reliable quality control.
- AN-NIR-053Moisture analysis of ethanol-hydrocarbon blends by Vis-NIR spectroscopy
This Application Note shows that visible near-infrared spectroscopy (Vis-NIRS) can determine water content in ethanol-hydrocarbon blends. Vis-NIRS is a fast alternative to conventional lab methods: it accelerates raw material inspection, process monitoring, and final product control.
- AN-NIR-054Quality Control of Shampoo
Determination of sodium laureth sulfate (SLES), cocamidopropyl betaine (CABP), cocamidopropylamine oxide (CAW), cocamide diethanolamine (DEA), and carbopol in shampoo is a cost- and time-intensive process due to the use of large volumes of chemicals per analysis. This application note demonstrates that the DS2500 Solid Analyzer operating in the visible and near-infrared spectral region (Vis-NIR) provides a cost-efficient and fast solution for a simultaneous determination these parameters in shampoo. With no sample preparation or chemicals needed, Vis-NIR spectroscopy allows for the complete analysis in less than a minute.
- AN-NIR-055Determination of water content in moisturizing skin creams using near-infrared spectroscopy
Near-infrared spectroscopy (NIRS) was used for quality control of skin creams. A model for the quantification of the water content was developed based on Karl Fischer titration (KF), enabling fast and reliable atline analysis and final product quality control.
- AN-NIR-056Quantification of five effective components in pesticides by visible near-infrared spectroscopy
This Application Note shows that visible near-infrared spectroscopy (Vis-NIRS) can be used for the quantification of five effective insecticide and herbicide components (Abamectin emulsifiable concentrate (EC), Emamectin EC, Cyhalothrin EC, Cypermethrin and Glyphosate) in pesticides. Vis-NIRS is an excellent alternative to conventional lab methods, saving both cost and time.
- AN-NIR-057Quantification of Baicalin content in scutuellaria baicalensis powder (herbal supplements) by Vis-NIRS
This Application Note shows that visible near-infrared spectroscopy (Vis-NIRS) can be used for the quantification of Baicalin content in herbal supplements. Vis-NIRS is a good alternative to the conventional lab method (HPLC) and can save both cost and time.
- AN-NIR-058Quantification of color intensity of diluted textile dye by visible near-infrared spectroscopy
This Application Note shows that the visible range of the Metrohm Vis-NIR analyzer can be used to quantify the color intensity of dyes, providing comparable results to the reference analysis UV-Vis. The NIR region can be used in addition to distinguish between different dye types or different suppliers and can identify impurities in the undiluted dyes during raw material control. The combination of the visible and near-infrared wavelength ranges offer the benefit that only one analyzer is required to receive results on multiple parameters in a 30-seconds-scan results on both cost and time saving.
- AN-NIR-060Quality Control of Polyamides
Functional group and viscosity analysis (ASTM D789) of polyamides can be a lengthy and challenging process due to the sample’s limited solubility. This application note demonstrates that the DS2500 Solid Analyzer operating in the visible and near-infrared spectral region (Vis-NIR) provides a cost-efficient and fast solution for a simultaneous determination of the intrinsic viscosity as well as the amine, carboxylic, and moisture content in polyamides. With no sample preparation or chemicals needed, Vis-NIR spectroscopy allows for the analysis of polyamides in less than a minute.
- AN-NIR-061Determination of aliphatic alcohols in alcohol mixtures using visible near-infrared spectroscopy
This Application Note describes a fast, nondestructive, and reliable method for the determination of the chemical composition of alcohol mixtures exemplified by ethanol/isopropanol mixtures. With visible near infrared spectroscopy (VIS-NIRS), results are available in real-time, thus making NIRS highly suited for fast quality control.
- AN-NIR-062Determination of sun protection factor in creams using visible near-infrared spectroscopy
This Application Note shows that visible near-infrared spectroscopy (Vis-NIRS) can determine the sun protection factor (SPF) of sunscreen products. Thanks to measurement durations of less than 30 seconds, NIR spectroscopy is ideally suited for rapid and reliable quality control.
- AN-NIR-063Content uniformity test of pharmaceutical solid dosage forms using NIR spectroscopy
Uniformity of dosage units must be tested for QC purposes in the pharma industry. NIRS gives results in seconds along with the quantification of APIs and excipients.
- AN-NIR-064Quality control of ammonium nitrate
Specialty chemicals have to fulfill multiple quality requirements. One of these quality parameters, which can be found in almost all certificates of analysis and specifications, is the moisture content. The standard method for the determination of moisture content is Karl Fischer titration.This method requires reproducible sample preparation, chemicals, and waste disposal. Alternatively, near-infrared spectroscopy (NIR) can be used for the determination of moisture content. With this technique, samples can be analyzed without any preparation and without using any chemicals.
- AN-NIR-066Content uniformity of pharmaceutical solid dosage forms using Vis-NIR spectroscopy examplified on cefixime tablets
This Application Note presents Vis-NIR spectroscopy as a viable alternative to determine API content in cefixime tablets without sample preparation.
- AN-NIR-067Simultaneous determination of multiple quality parameters in epoxy resins using Vis-NIR spectroscopy
This Application Note demonstrates the feasibility of Vis-NIRS for the simultaneous determination of multiple chemical and physical parameters in epoxy resins. Vis-NIRS is a fast alternative to conventional lab methods: it accelerates raw material inspection, process monitoring, and final product control.
- AN-NIR-068Quality Control of Isocyanates
Determination of isocyanates (ASTM D7252) is a challenging procedure due to the reactivity of these organic species with atmospheric moisture, as well as their toxicity. Furthermore, HPLC analysis typically used for this kind of analysis involves sample preparation steps and chemicals, with each measurement taking up to 20 minutes to complete. This application note demonstrates that the XDS RapidLiquid Analyzer operating in the visible and near infrared spectral region (Vis-NIR) provides a chemical-free and fast solution (under one minute) for determination of isocyanate content.
- AN-NIR-069Determination of sodium dodecyl sulfate in toothpaste using Vis-NIR spectroscopy
Rapid quality control for toothpaste is achieved by Metrohm`s Vis-NIR analyzers. Vis-NIR technology offers significant advantages compared to standard reference analysis. It is a cost effective and safe method because no hazardous chemicals are used.
- AN-NIR-070Quantification of nicotine and glycerin in e-liquids using visible near-infrared spectroscopy
This Application Note describes a fast method for the simultaneous quantification of nicotine and glycerin in liquid mixtures used for electronic cigarettes. With visible near infrared spectroscopy (VIS-NIRS), results are available without sample preparation, thus making VIS-NIRS highly suited for fast quality control.
- AN-NIR-071Automated acid number determination in lubricants with near-infrared spectroscopy
Acid Number (AN) analysis of lubricants (ASTM D664) can be a lengthy and costly process due to usage of large amounts of chemicals and required cleaning steps of the analytical equipment between each measurement. This application note demonstrates that the XDS RapidLiquid Analyzer operating in the visible and near-infrared spectral region (Vis-NIR) provides a cost-efficient, fast alternative for the determination of the acid number of lubricants. With no sample preparation or chemicals needed, Vis-NIR spectroscopy allows for the analysis of AN in less than a minute.
- AN-NIR-072Rheological additive and wax in packaging paint by Vis-NIR spectroscopy – Multiple parameters with one measurement
Packaging has become an indispensable part in the food manufacturing process. To improve the appearance and properties of the packaging, a wide variety of coatings and inks are used. Different additives enhance rheological properties, control the wetting dispersion, or in the case of wax increase abrasion resistance. The regulations of these coatings in food packaging applications are very strict in some countries, creating the need for close monitoring of the production process.A fast, reliable, and simple to use solution for quantifying rheological additives and wax in such coatings is Visible-Near Infrared Spectroscopy (Vis-NIRS). Both parameters are determined simultaneously by Vis-NIRS in less than a minute.
- AN-NIR-073Determination of water activity in tablets with the OMNIS NIR Analyzer
Water activity is an important parameter to measure for non-sterile pharmaceutical quality and stability. The OMNIS NIR Analyzer provides this data within seconds.
- AN-NIR-074Quality control of liquid laundry detergents by NIR spectroscopy
This Application Note shows how NIRS is used for the multiparameter analysis of dry matter, pH value, viscosity, and surfactant content in liquid laundry detergent.
- AN-NIR-075Naphtha in soil by Vis-NIR spectroscopy – A straightforward solution for testing laboratories Naphtha
Naphtha is the first petroleum product during the distillation process of crude oil or coal tar. It is primarily used as a base material for the production of gasoline or as a solvent. Accidental spills occur regularly at many locations throughout the world, leading to soil contamination.Investigation of contaminated sites is usually performed using gas chromatography, for which the soil sample has to be frozen, grinded, and subsequently extracted prior to the analysis. Using Visible-Near Infrared Spectroscopy such sample preparation steps are not necessary at all, making this method a viable, fast, and simple to use alternative.
- AN-NIR-076Quality control of polyvinyl alcohol
Polyvinyl alcohol (PVA) is a linear polymer, used in a variety of medical products (e.g. eye drops). Here, the degree of alcoholysis is an important index for the water solubility, viscosity, and adhesion of the product. The degree of alcoholysis is defined as the percentage of hydroxyl functional groups compared to the total functional groups accessible in the molecule. Conventional alcoholysis determination can take up to six hours per sample. Compared to the primary method, analysis with near-infrared spectroscopy (NIRS) only takes one minute. The following application note describes the determination of the degree of alcoholysis by NIRS.
- AN-NIR-077Moisture analysis in caprolactam
Caprolactam is an important polymer used for the production of Nylon 6, which is the base material for industrial fibers. Due to its commercial significance, many different synthesis methods have been developed over the years. Caprolactam is hygroscopic and water soluble, therefore it is important to have a reliable analysis technique for water determination. Analyzing the water content by conventional methods requires each sample to be weighed, dissolved, heated, and titrated. Compared to the primary method, near-infrared spectroscopy (NIRS) offers unique advantages: it generates reliable results within seconds, but it does not need any sample preparation nor does it create chemical waste.
- AN-NIR-078Automated moisture analysis in pharmaceutical peptides
The quantification of residual moisture in lyophilized pharmaceutical peptides is an important measure for quality control in the pharmaceutical industry. For development purposes, such measurements are necessary and routinely performed during stability studies and to optimize the freeze-drying process (lyophilization). Currently, Karl Fischer titration is widely used for moisture determination in routine analysis. However, this method is time consuming and destroys the sample during analysis. This Application Note shows that near-infrared spectroscopy (NIRS) is a fast, reagentless, non-destructive method to determine moisture content in lyophilized pharmaceutical products.
- AN-NIR-079Moisture analysis in fertilizer products
Moisture content is one of the most commonly measured properties of fertilizers. Globally, regulations for different fertilizers vary, but local legal limits ensure that the maximum amount of water must not be exceeded. Next to gravimetric methods, Karl Fischer titration is often used for accurate moisture determination.Compared to these methods, near-infrared spectroscopy (NIRS) offers unique advantages: it generates reliable results within seconds, and at the same time does not create chemical waste. This Application Note explains how NIRS can offer fast, reagent-free analysis of moisture content in various fertilizer products.
- AN-NIR-080Quality Control of Diesel
The cetane index (ASTM D613), flash point (ASTM D56), cold filter plug point (CFPP) (ASTM D6371), D95 (ISO 3405), and viscosity at 40°C (ISO 3104) are key parameters to determine for diesel quality. The primary test methods are labor intensive and challenging due to the need to use different analytical methods. This application note demonstrates that the NIRS XDS RapidLiquid Analyzer provides a cost-efficient and fast solution (under 1 minute) for the simultaneous determination of these key parameters in diesel.
- AN-NIR-081Quality Control of Polyethylene
Determination of the density of polyethylene (PE) (ASTM D792) is normally a challenging procedure due to reproducibility difficulties. Measurement via FT-IR can be problematic when larger sample sizes must be analyzed due to sample inhomogeneity. This application note demonstrates that the DS2500 Solid Analyzer operating in the visible and near-infrared spectral region (Vis-NIR) provides a reliable and fast solution for determination of the density of PE. With no sample preparation or chemicals needed, Vis-NIR spectroscopy allows the analysis of larger, inhomogeneous sample sizes of PE in less than a minute.
- AN-NIR-082Quality Control of Polypropylene
Polypropylene (PP) is a general purpose resin widely used in industries such as electronic manufacturing and construction, as well as in packaging materials. PP resins must be melted first in order to be formed into the intended shape, and therefore flow properties are important characteristics which affect the production process. The standard procedure to analyze melt flow rate (MFR) requires a significant amount of work with packing the sample, preheating, and cleaning. With no sample preparation or chemicals needed, Vis-NIR spectroscopy allows the analysis of MFR in less than a minute.
- AN-NIR-083Quality Control of HDPE, LDPE, and PP
Identification of individual polymers with FT-IR spectroscopy can be a challenge due to sample inhomogeneity especially when larger sample sizes need to be analyzed. This application note demonstrates that the DS2500 Solid Analyzer operating in the visible and near infrared spectral region (Vis-NIR) provides a reliable and fast solution for the identification of high-density polyethylene (HDPE), low-density polyethylene (LDPE), and polypropylene (PP). With no sample preparation or chemicals needed, Vis-NIR spectroscopy allows the identification of larger inhomogeneous sample amounts in less than a minute.
- AN-NIR-084Quality Control of Silicone rubber
Determination of the vinyl content of silicone rubber is a lengthy and challenging process. First, the vinyl groups must be converted to ethylene by reacting with an acid, followed by the determination of the produced ethylene with gas chromatography (GC).This application note demonstrates that Vis-NIR (visible near-infrared) spectroscopy provides a cost-efficient and fast solution for the determination of vinyl content in silicone rubbers. With the DS2500 Solid Analyzer it is possible to obtain results in less than a minute without sample preparation or any chemical reagents.
- AN-NIR-086Quality Control of Diesel Exhaust Fluid
The quality control of diesel exhaust fluids (DEF) is key to ensure the optimal catalytic performance and prevent damage to the exhaust system in diesel vehicles. The standard method to determine urea content is measuring the refractive index (ISO 22241-2:2019). The issue is that although this method is fast, it is not as accurate as other methods (e.g., HPLC). This application note demonstrates that the DS2500 Liquid Analyzer provides a fast solution with high accuracy for the determination of urea in DEF. With no sample preparation or chemicals needed, visible near infrared (Vis-NIR) spectroscopy allows for the analysis of diesel exhaust fluids in less than a minute.
- AN-NIR-087Ethanol content in hand sanitizers
Safe and fast ethanol determination in hand sanitizers is possible with reagent-free near-infrared spectroscopy (NIRS). NIRS provides reliable results in a few seconds, quickly indicating when adjustments in formulation are necessary.
- AN-NIR-088Quality Control of CBD oils
Cannabidiol (CBD) is a popular natural remedy from the cannabis plant used in many pharmaceutical, food, and cosmetic products. Unlike tetrahydrocannabinol (THC), CBD is not psychoactive, making it an appealing option for those who are looking for relief from pain and other symptoms without mind-altering effects. CBD oil is made by extracting the cannabinoid from the plant, then diluting it with a carrier oil (e.g., coconut or hemp seed oil). The standard HPLC method requires 45 minutes to perform by highly trained analysts. In contrast to the primary method, Vis-NIR spectroscopy is a cost-efficient and fast analytical solution for the determination of cannabinoid content in edible oils.
- AN-NIR-089Quality Control of Laminates
In the semiconductor industry, thermoset resins combined with fabric or paper are used as an intermediate layer between substrates of printed circuit boards (PCB). These polymer-based sheets (laminates) are chosen depending on thickness and their thermomechanical and electrical characteristics. Near infrared spectroscopy (NIRS) is a fast, non-destructive and easy-to-use analytical method which allows the measurement of multiple key quality parameters in less than a minute. The following Application Note describes the determination of the transition time of PCB laminates by NIRS, a parameter correlating with the thickness, glass transition temperature, and tensile strength of the material.
- AN-NIR-090Quality Control of Mixed Phosphoric, Sulfuric, Nitric, and Hydrofluoric Acids
Fast and reliable detection of phosphoric, sulfuric, nitric, and hydrofluoric acids with near-infrared spectroscopy in under one minute.
- AN-NIR-091Quality Control of Mixed Acetic, Hydrofluoric, and Nitric Acids
This application note discusses an alternative near-infrared (NIR) spectroscopy method that can reliably determine all parameters within a minute, even in complex acid mixtures.
- AN-NIR-092Quality Control of PVC foils
PVC (polyvinyl chloride) foils with a PVDC (polyvinylidene chloride) coating are often used for high performance packaging films like pharmaceutical blister packs or in food packaging. In multi-layer blister films, the PVC serves as the thermoformable backbone structure, whereas the PVDC coating acts as a barrier against moisture and oxygen. The Water Vapor Transmission Rate (WVTR) and Oxygen Transmission Rate (OTR) are influenced by the composition and the thickness of the coating. A fast way to monitor PVDC coating thickness is with near-infrared spectroscopy. Results are provided in a few seconds, indicating when adjustments in the polymer production process are necessary.
- AN-NIR-093Quality Control of fermentation processes
The production of biofuels from renewable feedstock has grown immensely in the past several years. Bioethanol is one of the most interesting alternatives for fossil fuels, since it can be produced from raw materials rich in sugars and starch. Ethanol fermentation is one of the oldest and most important fermentation processes used in the biotechnology industry. Although the process is well-known, there is a great potential for its improvement and a proportional reduction in production costs. Due to the seasonal variation of feedstock quality, ethanol producers to need to monitor the fermentation process to ensure the same quality product is achieved. Near-infrared spectroscopy (NIRS) offers rapid and reliable prediction of ethanol content, sugars, Brix, lactic acid, pH, and total solids at any stage of the fermentation process.
- AN-NIR-094Bromine number in pyrolysis gasoline
This application note presents near-infrared spectroscopy (NIRS) as an alternative for bromine number determination in pyrolysis gasoline.
- AN-NIR-095Quality Control of Hand Sanitizers
This application note presents near-infrared spectroscopy (NIRS) for the rapid and reliable simultaneous quantification of ethanol, glycerol, hydrogen peroxide, and water content in hand sanitizer formulations.
- AN-NIR-096Water in diesel with NIRS
This Application Note highlights near-infrared spectroscopy as a faster, cost-effective alternative to KF titration for predicting water content in diesel fuel.
- AN-NIR-097Total base number in lubricants with near-infrared spectroscopy
Alkaline additives in engine lubricants are used to prevent the build-up of acids and as a result, they inhibit corrosion. The total base number (TBN) indicates the amount of basic additives present in samples and thus can be used as a measure for the degradation of the lubricant. The standard test method for TBN in lubricants is potentiometric titration according to ASTM D2896. This method requires the use of toxic reagents involves a labor-intensive cleaning procedure. In contrast to the primary method, near-infrared spectroscopy (NIRS) is a fast analytical technique which does not produce any chemical waste and completes the TBN analysis in less than one minute.
- AN-NIR-098Quality Control of PVC granulate
To monitor the quality of PVC (polyvinyl chloride), it is important to measure the molecular weight during the production process, as this parameter has a significant influence on chemical and mechanical stability as well as fire retardant properties. The standard method to determine PVC molecular weight, defined here as the average weight of the molecules that make up the polymer, is by size exclusion chromatography (SEC). This analytical method is time-intensive and requires trained personnel to perform. Determining the molecular weight of PVC is easier with near-infrared spectroscopy (NIRS). NIRS provides results in just a few seconds and can quickly indicate when adjustments to the production process are necessary.are necessary.
- AN-NIR-099Quality Control of fermentation broths
Cell fermentation processes are a reliable production method for small molecules and protein-based active pharmaceutical ingredients (APIs). The fermentation process requires monitoring of many different parameters to ensure optimal production. These quality parameters include pH, bacterial content, potency, glucose, and concentration of reducing sugars. Traditional laboratory analysis takes a significant amount of time and requires different analytical techniques to monitor these different quality parameters. Near-infrared spectroscopy (NIRS) offers a faster and more cost-efficient alternative to traditional methods for the determination of critical parameters in fermentation broths at any stage of the fermentation process.
- AN-NIR-100Ash determination in polyethylene
The standard test method for ash content analysis is thermogravimetric analysis (TGA). Although TGA is easy to perform, it is time-intensive and requires the use of nitrogen gas. In contrast to the primary method, near-infrared spectroscopy (NIRS) is a fast analytical technique which can measure multiple parameters including ash content in polymers within one minute.
- AN-NIR-101Quality control of dried cannabis
Typically, cannabis potency testing is performed by HPLC, but the drawback is that it requires chemicals and it is time-consuming. Near-infrared spectroscopy (NIRS) is a preferred method for quantification of THC, CBD and CBG in dried cannabis because it provides results in less than a minute and does not require any chemicals.
- AN-NIR-102Density of polyolefins measured by near-infrared spectroscopy
This Application Note shows the feasibility of NIR spectroscopy for the analysis of density in polyethylene granulates. Compared to the standard method, NIRS analysis shows a lower prediction error when air bubbles are present in PE pellets.
- AN-NIR-103Quality control of chocolate bars by near-infrared spectroscopy
Near-infrared spectroscopy (NIRS) is a fast, chemical-free analysis method for various quality parameters of chocolate bars without sample preparation. The NIRS solution is easy to use and can be used atline or in a quality control lab.
- AN-NIR-104Analysis of green coffee beans by near-infrared spectroscopy
Near-infrared spectroscopy (NIRS) is a fast, chemical-free analytical method for the simultaneous analysis of density, water activity, and moisture of green coffee beans.
- AN-NIR-105Roasted coffee analysis by near-infrared spectroscopy
Near-infrared spectroscopy (NIRS) is a fast, chemical-free alternative analytical technology for caffeine and moisture analysis in roasted coffee beans and grounds.
- AN-NIR-106Quality control of non-nutritive sweeteners with NIR spectroscopy
Near-infrared spectroscopy (NIRS) allows the simultaneous determination of sweeteners such as Stevia and sucralose in blends in less than one minute without any chemicals or sample preparation.
- AN-NIR-107Quality control of Bromobutyl rubber
The synthetic rubber known as Bromobutyl (BIIR) has many of the attributes of butyl rubber, but has better adhesion to other rubbers and metals, resulting in substantially faster cure rates. The simultaneous quantification of the bromine content, Mooney viscosity, volatile content, calcium stearate content, and functional bromide in BIIR can be easily performed with near-infrared spectroscopy (NIRS) without the use of chemicals.
- AN-NIR-108Measuring Brix and individual sugars in fruit juices with NIR spectroscopy
NIRS enables rapid, chemical-free analysis of glucose, fructose, sucrose, and Brix in fruit juices without sample prep, offering a fast alternative to traditional methods.
- AN-NIR-109Determination of Brix, fructose, glucose, and sucrose with NIRS
Key quality parameters in the food industry include sucrose, glucose, and fructose, and Brix (dissolved sugar content). Near-infrared spectroscopy (NIRS) allows fast simultaneous determination of multiple sugars without chemicals or any sample preparation.
- AN-NIR-110Quality control of sugarcane juice
Brix, Pol, juice purity, reducing sugars, and total recoverable sugars are some of the many quality control (QC) parameters that must be analyzed in sugarcane juice. An alternative to other analytical methods is near-infrared spectroscopy (NIRS). NIRS allows the fast, simultaneous determination of several QC constituents without chemicals or sample preparation.
- AN-NIR-111Iodine value, FFA, refractive index, and fatty acid composition in edible oils
Near-infrared spectroscopy can quickly determine multiple edible oil quality parameters simultaneously without sample preparation as shown in this Application Note.
- AN-NIR-112Intrinsic viscosity (IV) determination of recycled PET by NIR spectroscopy
Near-infrared (NIR) spectroscopy is able to determine the intrinsic viscosity of rPET in less than one minute without any sample preparation. This Application Note demonstrates that the Metrohm DS2500 Solid Analyzer operating in the visible and near-infrared spectral region (Vis-NIR) offers users an easier way to perform this analysis without the use of toxic chemicals.
- AN-NIR-113Research octane number (RON) determination in isomerate
The standard method to determine RON in isomerate is with expensive and maintenance-intensive engines. In contrast to this, the research octane number can also be analyzed by near-infrared spectroscopy (NIRS). NIRS provides accurate results within one minute without the need for any sample preparation or chemicals.
- AN-NIR-114Determination of RON, aromatics, benzene, olefins, and density in reformate by NIRS
The determination of key quality parameters of reformate—namely research octane number (RON, ASTM D2699-19), aromatic content (ASTM D5769-15), benzene content, olefin content, and density—requires time-consuming and laborious conventional methods. In contrast, the Metrohm DS2500 Liquid Analyzer can measure all of these parameters, providing results within one minute without any sample preparation.
- AN-NIR-115Multiparameter quality control of palm oil with NIR spectroscopy
Near-infrared spectroscopy (NIRS) quickly assesses key quality parameters in palm oil such as iodine value and fatty acid profile without sample preparation.
- AN-NIR-116Determination of iodine value in frying oils with NIR spectroscopy
Monitoring the iodine value in edible oil blends is crucial to produce vegetable oils with the desired properties. This Application Note displays the benefit of using the Metrohm NIRS DS2500 Liquid Analyzer for quality control in food laboratories.
- AN-NIR-117Analysis of moisture, ash, carbon, and volatile content in coal by NIRS
Conventional methods used to analyze moisture, ash, fixed carbon, and volatile content in coal samples, are time consuming and costly. Near-infrared (NIR) spectroscopy is excellently suited to determine all parameters simultaneously in less than one minute without any sample preparation.
- AN-NIR-118Quantification of cotton content in textiles by near-infrared spectroscopy
This Application Note demonstrates how the OMNIS NIR Analyzer Solid quickly determines the cotton content in various textile products within just 30 seconds.
- AN-NIR-119Moisture content and rheology determination of fluorinated polyolefins using NIRS
Near-infrared spectroscopy streamlines ethylene tetrafluoroethylene production by offering rapid, chemical-free analysis of melt flow rate and moisture content.
- AN-NIR-121Water content in propylene glycol monomethyl ether (PGME)
Near-infrared spectroscopy (NIRS) can determine water content in PGME (propylene glycol monomethyl ether) within seconds as shown in this Application Note.
- AN-NIR-122Quantification of water in lactose with the OMNIS NIRS Analyzer
This Application Note shows how easy it is to determine water content in the pharmaceutical excipient lactose with reagent-free near-infrared spectroscopy.
- AN-NIR-123Flour analysis by near-infrared spectroscopy (NIRS)
NIR spectroscopy offers fast, chemical-free analysis of ash, protein, moisture, and rheological properties in flour – ideal for routine lab or atline quality control.
- AN-NIR-124Polyethylene content determination in polypropylene pellets by NIRS
Polypropylene and polyethylene can pose recycling challenges. With near-infrared spectroscopy (NIRS), users receive polyolefin composition results in seconds.
- AN-NIR-125Determination of olive oil quality parameters and adulteration with NIR spectroscopy
Near-infrared spectroscopy (NIRS) offers a fast, solvent-free alternative to traditional methods for assessing olive oil quality and detecting potential food fraud.
- AN-NIR-126Biodiesel content in diesel with near-infrared spectroscopy
Determination of the biodiesel content in diesel with NIR spectroscopy is fast and requires no sample preparation nor chemicals, reducing workload and costs.
- AN-NIR-127Feed analysis with near-infrared spectroscopy (NIRS)
NIR spectroscopy enables fast, reagent-free analysis of fat, moisture, protein, fiber, ash, and starch in animal feed, streamlining quality control with no sample prep.
- AN-NIR-128Milk powder analysis by near-infrared spectroscopy
Near-infrared spectroscopy saves time and resources by simultaneously measuring key quality parameters like lactose, moisture, fat, and protein content in milk powder.
- AN-NIR-129Dried pet food analysis by near-infrared spectroscopy (NIRS)
This study shows how a pre-calibrated NIRS instrument is used for multiparameter analysis of several pet food quality indicators like protein, moisture, fat, and ash.
- AN-NIR-130Multiparameter hops analysis by near-infrared spectroscopy (NIRS)
NIRS can simultaneously measure several quality parameters in hops like cohumulone, hop oils, and moisture content, the hop storage index (HSI), and alpha and beta acids.
- AN-NIR-131NIRS analysis of forages
NIR spectroscopy enables fast, reliable analysis of key quality parameters in alfalfa forage (e.g., protein, fiber, and moisture) without any sample preparation.
- AN-NIR-132Almond analysis with near-infrared (NIR) spectroscopy
This Application Note shows how NIR spectroscopy is used to determine the water content (moisture content), protein content, and fat content in whole and ground almonds.