Indication of the titration endpoint of the weakly alkaline or weakly acidic terminal groups in non-aqueous solution is frequently not easy. An improvement is possible by using a suitable titrant (TBAH = tetrabutylammonium hydroxide for terminal carboxyl groups; perchloric acid for terminal amino groups).
An improvement in the evaluation can also be achieved by choosing benzyl alcohol as the solvent.
The choice of electrode combination and the measuring setup is also important. Differential potentiometry using the three-electrode technique results in a great improvement in titrations in poorly conducting solutions. Noisy signals are eliminated.