Iodine in a pharmaceutical product using Combustion Ion Chromatography with Inline Matrix Elimination
AN-CIC-005
pt_BR
<p>The iodine content in numerous iodized X-ray contrast media (ICM) is around 50% and is determined with great accuracy using Combustion Ion Chromatography. Large quantities of H<sub>2</sub>O<sub>2</sub> (1,000 mg/L) are required for complete absorption of the iodine. Similarly, the concentration of the internal standard should be 50 mg/L. The water content of the X-ray contrast media is determined by means of Metrohm's Karl Fischer oven method and incorporated in the final calculation.<br/><br/>Keyword: pyrohydrolysis</p>
The iodine content in numerous iodized X-ray contrast media (ICM) is around 50% and is determined with great accuracy using Combustion Ion Chromatography. Large quantities of H2O2 (1,000 mg/L) are required for complete absorption of the iodine. Similarly, the concentration of the internal standard should be 50 mg/L. The water content of the X-ray contrast media is determined by means of Metrohm's Karl Fischer oven method and incorporated in the final calculation.
Keyword: pyrohydrolysis