Recommendations for converting a manual titration procedure into an automated titration procedure
WP-063
fr
This white paper summarizes the steps involved in converting an existing manual titration procedure to semi-automated or automated titration procedures. It discusses topics such as selecting the right electrode and titration mode. For a better understanding, the discussion topics are illustrated with three examples.
Manual titration remains a cornerstone in pharmaceutical analysis, but automation offers significant advantages in reliability, reproducibility, and data integrity. This White Paper, developed by Metrohm in collaboration with USP, walks you through the essential steps and considerations for converting manual titration methods to semi-automated or fully automated procedures.
Three real-world case examples illustrate how to adapt manual procedures to automated systems, including sensor selection and method adjustments.
Key topics covered in this White Paper are:
- Selecting the right sensor: the first and most critical step is choosing the appropriate electrode for your titration type (e.g., acid-base or redox). The White Paper provides a comprehensive table matching common titrants and indicators to recommended sensors, ensuring you can select the best fit for your application.
- Adjusting sample size and diluent volume: automation often requires changes to sample size and solvent volume to ensure proper electrode immersion and optimal titrant consumption. The White Paper offers clear recommendations for these adjustments, minimizing waste and maximizing accuracy.
- Choosing the titration mode: learn about endpoint, monotonic, and dynamic titration modes – how they work, when to use them, and their impact on precision and speed.
Download white paper
We have compiled a comprehensive white paper and several application documents that address typical questions that arise with the change from manual to automated titration. This white paper is intended to help follow the recommendations by USP.