The stability of the Metrosep A Supp 5 - 250/4.0 column was determined in long-term laboratory tests. Two injection series each were run on six days in a row. Each series was comprised of nine tap water injections, three check standard injections and six tap water injections. The IC system was shut down on the seventh day of each series. As a whole, the IC system ran over 10 weeks and counted a total of 2,150 injections. The results show an outstanding reproducibility and verify the high column stability.