Fluoride is commonly used in dental products to help prevent tooth decay. If the products are intended to prevent the formation of cavities (carries), then it is regulated by the US Food and Drug Administration (USFDA) as an Over-the-Counter (OTC) Drug. Previously, the assay of Fluoride in oral solution was done by Ion selective electrode and identification was done by tedious wet chemistry method. USP has updated this monograph for Assay and identification tests with Ion Chromatography using L46 packing. The Metrosep A Supp 1 - 250/4.6 column fulfills all USP acceptance criteria. It therefore is a viable alternative separation column for the determination of sodium fluoride in oral solutions.

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