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电位滴定仪

电位滴定仪

环球前列的电位滴定解决方案的供应商，给您提供创新的电位滴定仪、电位滴定系统及附件和专业的知识。

产品型号 知识拓展 附件 为什么选择瑞士万通？ 常见问题

无论您有什么需求——我们都有适合您的电位滴定仪

瑞士万通电位滴定仪组合包括经济、紧凑和独立的选择，以及现代和全自动的系统。使用筛选来完善您的搜索，找到符合您需求的自动电位滴定仪。

查询电位滴定仪相关应用

可靠、准确的测量 ——电位滴定仪组件

为什么选择瑞士万通电位滴定仪？—— 我们是环球市场的专业制造者

瑞士万通成立于 1943 年，现已发展成为环球先进的电位滴定分析专业仪器和解决方案提供者。

  • 从瑞士万通可获得全系列电位滴定仪：从紧凑型台式到模块化自动滴定系统，还有可用于电位滴定、容量法和库仑法卡尔费休滴定或过程分析的零配件和软件。
  • 瑞士制造，品质值得信赖。
  • 我们的服务和应用专家在环球 80 多个国家和地区提供本地支持。

点击下面链接，您可以阅读由我们应用专家撰写的 450 多份电位滴定应用报告：

查找应用报告

跳转至卡尔费休水分滴定和过程分析解决方案：

瑞士万通卡尔费休水分滴定仪

瑞士万通滴定过程分析仪

电位滴定仪 - 常见问题

Titrators are used to determine the concentration of a substance (analyte), which is dissolved in a sample. A reagent (titrant) is added gradually in a known volume to the sample until a chemical reaction reaches its endpoint, which is detected by a sensor.

How titrators work step-by-step:

  1. Sample addition: The sample is added to a vessel, often with a stirrer to ensure homogeneity.
  2. Titrant addition: The titrant is added manually or automatically in controlled volumes.
  3. Measurement & monitoring: Sensors continuously monitor the reaction. The titrator tracks changes in solution properties (e.g., voltage, color, conductivity) to detect the equivalence point.
  4. Endpoint detection: The endpoint is the moment when the reaction is complete.
  5. Result calculation & reporting: The titrator calculates the concentration of the analyte based on the volume of titrant used and generates a digital report.

 

Various sensors are available to monitor the reaction depending on the type of titration you are performing. Metrohm offers sensors for photometric, thermometric, redox, precipitation, complexometric, surfactant, aqueous or non-aqueous acid-base titration.

Check out our Webinar Center and our blog to learn more about titration:

Webinar: Basics of titration

Blog: Titration – definition and principles

Blog: Best practices for electrodes in titration

An automatic titrator is a laboratory instrument that performs titration procedures automatically, including sample and titrant addition, endpoint detection, and results calculation. Auto titrators have many advantages over manual titrators, such as faster analysis, reproducible measurements, and more.

Learn more about the fully automatic titrator from Metrohm:

Go to OMNIS titrators

Learn more about automatic titration and the advantages over manual titration in our blog:

Blog: Save money by using automated titration systems

Blog: Why consider automation – even for simple titrations

Titration is one of the oldest analytical techniques and is usually performed manually. However, manual titration presents many challenges. An autotitrator automates the titration process, delivering faster, more accurate, and safer results compared to manual titration. The video summarizes the 5 top reasons to switch from manual to automated titration.

  1. Easier preparation of the buret: An autotitrator fills the buret automatically.
  2. Step-by-step guidance: An autotitrator automatically transfers the sample size from the balance to the software or instrument, adjusts the stirring speed, and more.
  3. More reliable and reproducible endpoint evaluation: Automatic titrators ensure objective endpoint detection.
  4. Complete documentation according to GxP: Autotitrators ensure compliance with FDA CFR Part 11 and EudraLex Vol. 4, Annex 11.
  5. Safer handling of chemicals: Autotitrators reduce the exposure to hazardous chemicals.

In summary, the main benefits of an autotitrator are:

  • Speed and throughput: Faster analysis and higher sample throughput
  • Accuracy and reproducibility: Automated dosing and endpoint detection minimize human error
  • Efficiency: Frees lab personnel from repetitive tasks
  • Safety: Minimizes chemical exposure
  • Data management: Digital reports and integration with LIMS/ERP systems
  • Scalability: Modular accessories and automation options adapt to changing workloads

 

Learn more about autotitrators:

White Paper: Manual vs. Automated Titration: Benefits and Advantages to Switching

Webinar: The benefits of automating your titration applications

Blog: Why consider automation – even for simple titrations

Blog: How to transfer manual titration to autotitration

 

Choosing the right titrator depends on your sample type, analytical goals, and lab environment. Here are the key factors to consider:

Factors Tips
Type of titration
  • Potentiometric titration: Ideal for acid-base, redox, complexometric, and precipitation reactions.
  • Photometric: Suitable for colored, opaque, or non-aqueous samples.
  • Thermometric titration: Best for samples where traditional sensors may not work.
  • Conductometric titration: Useful for reactions involving ionic changes.
Sample characteristics
  • Consider whether your samples are liquids, solids, slurries, or gases.
  • Some titrators offer accessories like homogenizers or sample preparation modules to handle complex matrices.
Throughput & automation
  • For high sample volumes, look for titrators with autosamplers or robotic automation (e.g., Metrohm’s OMNIS Sample Robot).
  • Parallel titration capabilities can significantly boost lab efficiency.
Accuracy & reliability
  • Choose systems with precise dosing, sensitive sensors, and robust endpoint detection.
  • Look for instruments that support method validation and reproducibility.
Compliance & data management
  • Ensure compatibility with GLP/GMP, 21 CFR Part 11, and other regulatory standards.
  • Check for integration with LIMS, ERP, or ELN systems for traceability and audit readiness.
Modularity & scalability
  • Opt for a platform that grows with your lab. Metrohm’s OMNIS titrators allow expansion with additional modules and titration modes.
Support & service
  • Consider availability of training, application support, and service contracts.
  • Ask about software updates, warranty coverage, and repair turnaround times.

Our titration experts are happy to assist you with your questions:

Contact us

The most common indication methods for automated titrations are potentiometric and photometric endpoint (EP) determination.

In potentiometric EP determination, the difference in potential is measured: The concentration-dependent potential of a solution is measured using an indicator electrode against a reference potential, which is measured using a reference electrode. Combined sensors including both indicator and reference electrode are also available.

In photometric EP determination, a photometric sensor, such as the Optrode from Metrohm, is used to determine the change in intensity at a particular wavelength of a light beam passing through a solution.

Another kind of titration that is less well known is thermometric titration. Thermometric EP determination relies on detecting temperature changes during the titration reaction. A highly sensitive temperature sensor monitors the solution, and the endpoint is identified by a sudden change in temperature, which occurs due to the exothermic or endothermic nature of the reaction. This method is especially useful for titrations where no suitable electrode or photometric indicator is available.

Learn more about potentiometric, photometric, and thermometric endpoint determination in our blog:

Blog: Recognition of endpoints (EP)

Blog: Thermometric titration – the missing piece of the puzzle

Webinar: Thermometric titration

Fully automated titration systems increase efficiency, accuracy, safety, and reliability of your titrations. Automated systems are ideal for high-throughput labs, routine analysis, and when minimizing manual labor is critical.

The OMNIS Sample Robot from Metrohm, for instance, allows you to fully automate the analysis of up to 175 samples.

Learn more about automated titration:

Webinar: The benefits of automating your titration applications

High-throughput labs not only need instruments with a large sample capacity, they also look for a system which offers flexibility and modularity to adapt to changing applications or peaks in workload.

OMNIS titrators and the OMNIS Sample Robot form the perfect titration system for high-throughput laboratories. OMNIS offers parallel titration, modular expansion, and automated sample handling. Watch the video to learn more.

Yes, entry-level Metrohm titrators (i.e., Eco Titrators) deliver reliable accuracy when paired with proper electrodes and validated methods.

The accuracy of titrations does not only depend on the instrument, it is the sum of several factors that contribute to it:

  • Choice of a suitable electrode or indication method
  • Choice of a suitable cylinder volume
  • Choice of a suitable titration mode
  • Accuracy of sample size (weighing/pipetting)
  • Homogenization of the sample
  • Electrode cleaning and maintenance
  • Burette maintenance
  • Other factors, depending on the specific titration method

 

An overview on how to get correct and accurate titration results can be found here:

Blog: How to avoid titration errors in your lab

Blog: Validation of  titration methods

Webinar: Avoid titration mistakes through best practice sensor handling

Webinar: Troubleshooting titration: essential know-how for quality results

Metrohm’s Ti-Touch and OMNIS titrators offer audit trails, user management, and secure data handling for full regulatory compliance to 21 CFR Part 11.

Stand-alone titrators (without PC software): Ti-Touch

Software-controlled titrators: OMNIS

Validating a titration method ensures that the procedure delivers accurate, reproducible, and reliable results – especially when transitioning from manual to automated titration. Metrohm recommends following the validation framework outlined in USP General Chapter <1225> Validation of Compendial Procedures and ICH Guidance Q2(R1) Validation of Analytical Procedures: Text and Methodology, which includes the following key steps:

  • Perform standardization of the titrant using a primary standard or a pre-standardized solution
  • Assess the accuracy and precision of the titration results by performing reference measurements
  • Verify the linearity of your results, i.e., that the titration results are proportional to the analyte concentration across the expected range
  • Demonstrate specificity, i.e., that the method can accurately measure the analyte without interference from impurities, excipients, or degradation products.

Find more information:

Blog: Validation of titration methods

White paper: Recommendations for titration methods validation

 

Modern titration systems offer various data formats for transferring titration data to an external software (LIMS / ERP / ELN). The most common formats are:

  • PC/LIMS report
  • XML report
  • PDF
  • CSV

Any Metrohm titrator offers at least one of these options, either by transferring the corresponding data in a corresponding file to a USB memory stick or directly to a computer/network directory.

The OMNIS Software offers a convenient and secure data exchange between OMNIS and any 3rd party software (e.g., LIMS, ERP, ELN) by direct transfer based on the REST software architecture.

电位滴定仪的工作原理

电位滴定仪是用于测定溶解在样品中的物质（即分析物）的浓度。手动或自动添加已知体积的试剂（滴定剂），然后实时监测化学反应。根据滴定类型的不同，有多种电极可以选择。瑞士万通提供的电极可以用于光度滴定、氧化还原滴定、沉淀滴定、络合滴定、表面活性剂滴定、水基酸碱滴定和非水基酸碱滴定。

查看我们的网络研讨会和博客，了解滴定的更多信息：

跳转至网络研讨会

博客：滴定中电极的多种应用

什么是自动电位滴定仪？

自动电位滴定系统可以自动执行滴定过程，包括样品制备、样品分析和结果计算。与手动滴定相比，自动滴定仪具有许多优势，例如分析速度更快、样品处理量更大、测量结果可重复等。

了解瑞士万通全自动电位滴定仪的更多信息：

OMNIS 奥秘一代全自动电位滴定仪

在我们的博客中了解更多有关自动电位滴定的信息以及与手动滴定相比的优势：

博客：使用自动滴定系统节约成本

博客：为什么要考虑自动化--即使是简单的滴定

有哪些类型的指示方法？

自动滴定非常常见的指示方法是电位测定和光度终点测定。

在电位测定中，测量的是电位差：电极测量溶液中随浓度变化的电位。瑞士万通同时也提供包括指示电极和参比电极的组合式电极。

在光度测定中，使用瑞士万通光度电极（ Optrode ）来确定通过溶液的光束在特定波长下的强度变化。

 

在我们的博客中了解有关电位测定和光度测定的更多信息：

博客：终点测定 (EP)

您想进一步了解电位滴定法吗？

下载免费应用

免费白皮书《实用滴定》中包含了滴定原理，详细介绍了滴定反应、指示方法、电极和滴定剂。在应用部分，讨论了酸碱滴定、沉淀滴定、氧化还原滴定、络合滴定和螯合滴定。