A convenient adsorptive cathodic stripping voltammetric (AdCSV) method has been developed for trace determination of uranium(VI) in drinking water samples using chloranilic acid (CAA). The presence of various matrix components (KNO3, Cl-, Cu2+, organics) can impair the determination of the uranium-CAA complex. The interferences can be mitigated, however, by appropriate selection of the voltammetric parameters. While problematic water samples still allow uranium determination in the lower µg/L range, in slightly polluted tap water samples uranium can be determined down to the ng/L range, comparable to the determination by current ICP-MS methods.