Potassium and sodium in bicarbonates and citric acid effervescent tablets for oral solution as per USP

Within the scope of the USP monograph modernization, potassium and sodium are determined in bicarbonates and citric acid effervescent tablets for oral solution applying cation chromatography with direct conductivity detection. The separation is performed on a Metrosep C 6 - 150/4.0 column (L76). All acceptance criteria are fulfilled. The USP41 monograph for “Potassium and sodium bicarbonates and citric acid effervescent tablets for oral solution” performs the assay of potassium by flame photometry.