Application Finder

Accurate analysis of complexing agents in galvanic baths is possible with inline Raman spectroscopy. This Application Note shows an example using a 2060 Raman Analyzer.

This Process Application Note presents a method to accurately monitor lactic acid and glucose inside a bioreactor in «real-time» with the 2060 Raman Analyzer from Metrohm Process Analytics.

Boric acid is growing in demand for various industrial applications, but requires a more cost-efficient and environmentally friendly production process. This Application Note describes the performance of a Raman process analyzer (PTRam) when measuring low-concentration boric acid and sodium sulfate solutions (<100 mg/L) during boric acid production.

Etching is a vital process in semiconductor fabrication, involving the chemical removal of layers from the wafer substrate. Strict quality control measures are necessary to determine acid etchant concentrations in mixed acid solutions (e.g., SPM, DSP, or DSP+), critical for optimizing etch rate, selectivity, and uniformity during multiple wafer etching steps. This application presents a method to measure sulfuric acid and hydrogen peroxide in etching baths simultaneously using Raman spectroscopy with the PTRam Analyzer from Metrohm Process Analytics.

This e-book explains how Raman and near-infrared (NIR) spectroscopy enable rapid, nondestructive polymer analysis, ensuring high quality while reducing costs and waste.

Polyurethanes are a class of synthetic polymers formed by reacting liquid di/polyisocyanates and polyols with a catalyst and various additives in a reactor. Polymer properties are modified with stepwise additions of these chemicals at different points in time depending on whether the process has reached an equilibrium. NCO functional groups from unreacted isocyanates must be quenched at the end for a finished product, and this parameter must be known to determine the proper chemical mixing ratio. A fast, non-destructive real-time measurement of %NCO can be obtained by using NIR spectroscopy with a probe seated directly in the reactor.

This Application Note describes an NIR method for monitoring the esterification process in butyl acetate production. The developed NIR method shows excellent analytical performance equivalent to that obtainable with more time-consuming GC methods.

This Process Application Note provides a detailed account of the inline assessment of moisture during a pilot scale granulation process using a 2060 The NIR Analyzer.

In the pharmaceutical industry, the fluid bed granulator/dryer is an integral point in the manufacture of powdered materials. Residual moisture must be kept within certain specifications to avoid fracturing of particles or caking (stickiness) of the bulk material. Current methods are slow and cumbersome, which can lead to damaged or degraded product. The ability to monitor the residual moisture content inline after drying is possible with near-infrared spectroscopy (NIRS). The 2060 The NIR Analyzer offers fast, reagent-free, nondestructive analysis of residual moisture of powders with a fluid bed probe specifically designed for these applications.

This Process Application Note presents a method to accurately monitor low levels of moisture in tetrahydrofuran (THF) in «real-time» safely, reliably, and optimally with a 2060 The NIR Analyzer from Metrohm Process Analytics. Due to the hazardous and hygroscopic nature of THF, a single explosion-proof inline process analyzer is the preferred solution for industries to reduce chemical treatment, improve product quality, and increase profits.

Well-mixed active substances for medications are indispensable in the pharmaceutical industry. This applies not only to the pharmaceutical active ingredient but also for lubricants, binding agents, explosives, oxidants and dyes. Analysis of these active ingredients is expensive; they are also only rarely analyzed as a rule. The progress of the mixing procedures can be followed conveniently with NIR spectroscopy, on the one hand using visual comparisons and on the other by means of spectral algorithms. The progress of mixing processes can be predicted in real time with the help of the spectrum when the latter is used.

Adulteration in the food industry is a significant concern due to potential health risks and changes in product quality and nutrition. Detecting such adulteration is challenging, however, to ensure high-quality products, precise measurements during the manufacturing process are essential for identifying any contamination in raw materials and final products. This Process Application Note details the inline analysis of potato starch in the wheat flour manufacturing process with a 2060 The NIR Analyzer from Metrohm Process Analytics.

This Application Note describes the utilization possibilities of a new sensor design that permits, in combination with an NIRS XDS Process Analyzer, the determination of solvent residues in a High-Shear Granulator during the drying phase. This system configuration reduces the scattering of the density distribution of the powder samples so that it is possible, directly in the process, to model the water and solvent content precisely.

This Process Application Note presents a method to closely monitor low levels of moisture in propylene oxide safely and reliably by using a single explosion-proof inline process analyzer.

A safer way to monitor moisture content in crude distillation unit overhead fractions is with inline near-infrared spectroscopy using the 2060 The NIR-Ex Analyzer.

This Application Note describes how NIR spectroscopy can be used to determine residual lignin content in wood pulp. Using the major absorbance peaks of both lignin and cellulose in the second derivative spectra, the residual lignin content in wood pulp can be monitored during paper production.

Rapid inline monitoring of the major SC1/SC2 bath constituents is possible with reagent-free near-infrared spectroscopy, e.g., the 2060 The NIR-R Analyzer.

Many fermentation quality parameters can be monitored simultaneously directly in the tank with inline near-infrared spectroscopy, such as the 2060 The NIR Analyzer.

In refineries, high octane products are desired since they are used to produce premium gasoline. Catalytic reforming converts heavy naphtha into a high octane liquid product called reformate (a mixture of aromatics and iso-paraffins C7 to C10). The reformate must be constantly monitored to ensure high throughput along the refining process. Traditionally, the octane numbers can be measured by two different methodologies: Inferred Octane Models (IOM) and laboratory octane engine analysis. However, these do not provide «real-time» results and require constant maintenance and human intervention to adapt to current operation conditions. «Real-time» analysis of the octane number in fuels can be performed online via near-infrared spectroscopy (NIRS) technology, which fits well within the international standards (ASTM). Utilization of a Metrohm Process Analytics NIRS XDS Process Analyzer (ATEX version) in conjunction with a sample preconditioning system makes analysis of the octane number simple, fast, and reliable, allowing quick adjustments to the process for a better quality product and higher profitability.

This Process Application Note presents a way to closely monitor multiple parameters simultaneously during the dioctyl terephthalate production process with near-infrared spectroscopy.

Propylene oxide (PO) is a major industrial product used in assorted industrial applications, mainly for the production of polyols (the building blocks for polyurethane plastics). Several production methods exist, with and without co-products. This white paper lays out opportunities to optimize PO production for safer and more efficient processes, higher quality products, and substantial time savings by using online process analysis instead of laboratory measurements.

This White Paper explores the critical role of advanced online and inline process analysis in brine chlorine operations, emphasizing their advantages over traditional methods.

OMNIS Client/Server boosts business performance with scalable server management, cutting costs by reducing hardware, energy use, and maintenance across locations.