Metrohm Inline Sample Preparation (MISP) for difficult sample matrices

Metrohm Inline Sample Preparation (MISP) puts an end to manual sample preparation for ion chromatography.

MISP stands for methods developed by Metrohm that allow you to fully automate the preparation of even the most challenging samples.

Not only will you increase sample throughput but also improve accuracy and reproducibility of analyses and results.

Inline Ultrafitration combines sample introduction with immediate filtration and removes any particles from the sample. As a result, the analytical column is protected from contamination and its service life is considerably increased.

• Fully automatic filtration (0.2 μm) of samples during sample introduction
• More than 100 samples with one filter, because carryover from sample to sample is negligibly small (<0.1%)
• Cost-saving solution for routine analysis

Metrohm Inline Dialysis not only removes particles from the sample to be analysed, but also oil drops and colloids.

Emulsions, samples containing fats and proteins (e.g., dairy products), body fluids and strongly polluted wastewater can be reliably analyzed without damaging the column or the suppressor.

Inline Dilution means all you need to do is place your samples on the rack of your sample processor. The system provides automatic dilution of the sample depending on a predefined concentration limit or the automatically calculated optimum dilution factor. Your results are always reliable, because they are within the calibration range.

• Automatic sample dilution during sample introduction
• Unique dilution system based on logical decisions of the system for the analysis with the optimal dilution factor
• Accurate and reliable results, irrespective of the initial concentration of the sample

Metrohm intelligent Partial Loop Injection (MiPT) automatically adjusts the injection volume to the concentration of the sample.

This technique, too, makes sure that the results are always within the calibration range.

Metrohm intelligent Pick-up Injection (MiPuT) is ideally suited for sample volumes as small as a few µL.

There is no sample loss, only a minimum of sample volume is required for an injection.

Metrohm Inline Extraction transfers water-soluble components from a non-polar organic phase into an aqueous phase for subsequent injection (after Inline Dialysis).

Cation analysis in biodiesel is one of the applications.

Metrohm Inline Matrix Elimination allows you to separate ionic analytes from the uncharged matrix without the use of sample preparation cartridges (SPE).

Ion analysis in organic solvents is one of the applications.

Metrohm Inline Preconcentration uses a preconcentration column instead of a sample loop. A defined volume of sample is passed over the preconcentration column, the relevant ions are retained, and the accumulated ions are eluted onto the separation column.

Metrohm Inline Preconcentration is ideally suited for trace analysis down to the ng/L concentration range.

Metrohm Inline Neutralization adjusts the pH of samples in order to prevent interferences with the analysis of anions.

When combined with Inline Preconcentration, Inline Neutralization makes trace anion analysis possible. Adjusting the pH right also prolongs the lifetime of the column.