Extending the scope of IC – hyphenated techniques

Hyphenated techniques

Interfacing Metrohm ion chromatographs with sophisticated sampling systems on the one hand (PILS, MARGA, and CIC) and/or universal, highly sensitive detection systems (IC-MS, IC-ICP/MS) on the other greatly extends the scope of ion chromatography.

Another option is the combination of Metrohm IC with complementary technologies from our portfolio, such as titration and voltammetry. TitrIC and VoltIC, respectively, enable dedicated multi-parameter analysis on a single system.

Hyphenated systems systems (16)

Combustion Ion Chromatography

Pyrohydrolytic Combustion Ion Chromatography (CIC) extends the range of automated ion chromatography to all kinds of combustible samples.

In CIC, samples are digested by pyrohydrolysis in an oven unit. The resulting gaseous compounds are passed into an absorption solution, which is transferred to a Metrohm ion chromatograph for subsequent injection and analysis.

CIC is the preferred method to determine various halogens and sulfur in matrices ranging from solids to viscous, liquid, and gaseous samples.
  • For fully automated routine analysis.
  • Superior to offline digestion methods both regarding sample throughput and accuracy of results
  • Qualification and quantification of concentrations for each of the different halogens

CIC complies with the following official standards

  • ASTM D7359-08 Standard Test Method for Total Fluorine, Chlorine and Sulfur in Aromatic Hydrocarbons and Their Mixtures by Oxidative Pyrohydrolytic Combustion followed by Ion Chromatography Detection (Combustion Ion Chromatography, CIC)
  • UOP991-11 Chloride, Fluoride, and Bromide in Liquid Organics by Combustion Ion Chromatography (CIC)
  • ASTM D5987-96(2007) Standard Test Method for Total Fluorine in Coal and Coke by Pyrohydrolytic Extraction and Ion Selective Electrode or Ion Chromatograph Methods
  • ASTM WK 24757 Work item for F, Cl, S in LPG
  • ASTM D7994-17 Standard Test Method for Total Fluorine, Chlorine, and Sulfur in Liquid Petroleum Gas (LPG) by Oxidative Pyrohydrolytic Combustion Followed by Ion Chromatography Detection (Combustion Ion Chromatography-CIC)

System for pyrohydrolytic combustion ion chromatography for halogen and sulfur determination

Tried and tested applications for CIC

  • Environmentally relevant substances (oil, plastic waste, glass, activated carbon, ...)
  • Electronic components (printed circuit boards, resin, cables, insulation, ...)
  • Fuels (gasoline, kerosene, crude oil, heating oil, coal, butane, propane, natural gas, catalysts, ...)
  • Plastics (polymers such as polyethylene, polypropylene, ...)
  • Coloring agents (pigments, paints, ...)
  • Pharmaceutical products (raw substances, intermediates, finished products, ...)
  • Foods (oils, spices, flavorings and fragrances, ...)
System for pyrohydrolytic combustion ion chromatography for halogen and sulfur determination


Air monitoring

Air pollution is a side effect of rapid industrialization and has become a widespread phenomenon.

When combined with sophisticated sampling systems, Metrohm ion chromatographs are a highly suitable tool for comprehensive monitoring of critical pollution parameters in ambient air.

24/7 air monitoring with MARGA

MARGA (Monitor for AeRosols and Gases in Ambient air) is a dedicated solution for online monitoring of ambient air.

MARGA collects the ionic load (anions and cations) from the aerosol and the gas fraction of a defined volume of ambient air, brings it into solution, and injects it into a dual channel ion chromatograph for subsequent analysis. Learn more about MARGA here.

MARGA M Air monitoring process analyzer for air quality monitoring

Particle Into Liquid Sampler (PILS)

The Particle Into Liquid Sampler, or PILS for short, transfers aerosols from a defined volume of ambient air to the aqueous phase.

PILS can be interfaced with any Metrohm ion chromatograph for multi-parameter analysis of aerosols. Learn more about this sampling system here.

The Particle Into Liquid Sampler transfers aerosols from an airstream to an aqueous phase

Combined measurements for comprehensive ion analysis

Comprehensive analysis of ionic components in water may require direct measurement, titration, ion chromatography, and voltammetry. Combine these techniques in a single analytical system to determine the complete range of ions out of one sample.

TitrIC flex – multiparameter analysis by combining titration and IC

The advantages of TitrIC flex at a glance:
  • Unique combination of titration, direct measurement, and ion chromatography (all from the same supplier)
  • Titrations and ion chromatography performed in parallel
  • All results in a common database and combined in a shared report
  • One autosampler for three analytical techniques
  • Titration and ion chromatography applied independently or in combination
  • Expandable, modular OMNIS Sample Robot for increased sample throughput
TitrIC flex for combined titration and ion chromatography analysis to measure temperature, conductivity, pH value, p and m values, calcium, magnesium, anions and cations

TitrIC flex I

TitrIC flex I for combined titrimetric and ion chromatography measurement

  • Direct measurement of temperature, conductivity, and pH value
  • Titrimetric determination of the p and m values, calcium and magnesium
  • Simultaneous anion determination by ion chromatography (after ultrafiltration)

> Learn more about TitrIC flex I

TitrIC flex II

TitrIC flex II for combined titration and anion and cation measurement with ion chromatography

  • Direct measurement of temperature, conductivity, and pH value
  • Titrimetric determination of p and m values
  • Simultaneous determination of anions and cations (including calcium and magnesium) by ion chromatography after ultrafiltration
  • Automatic ion balance calculation

> Learn more about TitrIC flex II


VoltIC Professional – ion chromatography and voltammetry combined

VoltIC Professional combines ion chromatography and voltammetry in a single, powerful system for trace ion analysis.

Learn more about VoltIC Professional here.

Combined voltammetry and ion chromatography system


IC/MS and IC-ICP/MS – coupling ion chromatography with mass spectrometry

You can expand the scope of what ion chromatography can do by coupling it with a mass spectrometer (IC-MS) or an inductively coupled plasma mass spectrometer (IC-ICP/MS). As a result, you will benefit from an increased sensitivity and selectivity. And this will allow you to perform determinations for which maximum reliability is a must, for instance the monitoring of toxic impurities (such as haloacetic acids) in drinking water.

In addition to yielding quantitative data, these techniques also provide qualitative information on the sample.

Ion chromatograph coupled with a mass spectrometer (ESI-MS or ICP-MS)