Water as an unwanted component
Although not an impurity in the strict sense, water can be regarded as an unwanted substance in pharmaceuticals. The quality, effectiveness, and shelf life of pharmaceutical products depend to a very great extent on their water content, which is why a great deal of importance is attached to water determination in pharmaceutical analysis.
Karl Fischer titration for accurate water determination
Thanks to its specific and selective reaction with water, Karl Fischer titration (KFT) is one of the most accurate and reproducible water determination methods. This is why numerous pharmacopeias have prescribed it for years as a standard method for fast, automation-ready water determination. Depending on the sample’s characteristics, different types of Karl Fischer titrations are available.
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