Nicotine in E-liquids – Reliable and affordable determination by potentiometric titration

The vaping and electronic cigarette industries have grown impressively in the past decade. The mixtures used in these products are usually called «e-liquid», «e-fluid», or «e-juice». To ensure the quality of these e-liquids, testing the most important quality parameters, such as nicotine content, is required.


Nicotine in tobacco is usually determined by gas chromatography or liquid chromatography. Aqueous acid base titration is a much more affordable alternative for this determination. As e-liquids do not contain other components which might interfere with the titration, the aqueous acid base titration presented in this Application Note can be applied for nicotine determination.


This method is an affordable and reliable way to determine the nicotine content in e-liquids and their nicotine starting material, ensuring the quality of these products.