Inline moisture analysis in a pilot scale granulation process by NIRS

Top spray granulation in the pharmaceutical sector is a common method used to form granules from moist powdered materials in fluid bed dryers. The residual moisture must be kept within certain specifications to avoid fracturing of particles or caking (stickiness) of the bulk material. The ability to monitor the residual moisture content inline after drying is possible with near-infrared spectroscopy (NIRS). The NIRS PRO offers fast, reagent-free, nondestructive analysis of residual moisture of powders with a fluid bed probe specifically designed for these applications.