In-situ Monitoring of a Moisture-Induced Polymorphic Transition using Raman Spectroscopy and Gravimetric Vapor Sorption

The combination of Raman spectroscopy and vapor sorption techniques provides a comprehensive understanding of vapor-solid interactions of pharmaceutical materials as it relates to the structural properties.This paper investigates the in-situ monitoring of a moisture-induced polymorphic transformation (D-mannitol from delta to beta form) using a combined Raman-vapor sorption technique.