MISP method for inline removal of particles, large molecules, oil droplets of emulsions, etc. from the sample solution prior to injection.
The "Stopped Flow" dialysis method, patented by Metrohm, is based on the diffusion of analyte ions from the sample stream into a stationary acceptor solution. The sample continues to flow through the cell during the dialysis period. Consequently, the sample concentrations in the dialysis cell always remain constant. Equilibrium between the sample and the acceptor solution is attained for practical purposes within a few minutes.
This means that the concentrations of sample ions are almost identical in both solutions. Since there is no pressure difference during dialysis, the driving force is purely diffusion. Thus the risk of blocking the membrane pores is even lower than for Inline Ultrafiltration.
Typical applications: heavily contaminated waste waters, dairy products, fruit juices, emulsions.