Ion Chromatography Applications in the Pharmaceutical Industry
11/12/2015 11:00 AM - 11/12/2015 12:00 PM

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Metrohm Service
Presented by: Hari Narayanan, PhD, Product Marketing Manager, Metrohm USA

Trace-level inorganic analysis is gaining importance due to a growing list of toxic contaminants. Ion chromatography (IC) is a sensitive and reliable method to determine active ingredients, excipients, trace-level impurities and metabolites in pharmaceuticals and body fluids.  Low-molecular-weight amines find widespread use in the manufacturing of numerous pharmaceuticals. From raw materials to intermediate products, monitoring these amines is crucial as most of them are toxic and irritate the skin, mucous membranes and respiratory tract. Moreover, secondary amines can react with nitrite, forming carcinogenic nitrosamines. A large selection of separation columns and elution systems makes IC useful for analyzing these amines. Interfering effects caused by the sample matrix can easily be avoided by selection of the appropriate sample preparation method and choosing a suitable detection scheme.

This webinar will provide an introduction to Ion Chromatography with practical, industry-based applications. Gain a clear understanding of the challenges associated with IC method development based on real world samples.

Key Learning Objectives:
  • Basics of Ion Chromatography- Column chemistry, separation mechanism and detection techniques
  • Anion & organic acid determination in various pharmaceutical matrices
  • Residual amine determination in pharmaceutical products
  • Combustion Ion Chromatography and its application in pharmaceutical industry