Fully automated sample preparation for the content determination of tablets

Metrohm’s application chemists regularly participate in scientific conferences where they present the latest results of their research in technical posters.

These posters comprise condensed information on instrumentation, sample preparation, analysis, and results.

Intro

8.000.6024 Fully automated sample preparation for the content determination of tablets
Benzbromaron is one of the main uricosuric drugs currently used. In addition to sophisticated and expensive LC-MS and GC-MS methods, benzbromaron can be effectively determined by titration with sodium hydroxide solution using a straightforward, fully automated sample preparation method. A high-frequency homogenizer comminutes one or three tablets within 90 or 120 s respectively. The overall analysis time is 8 minutes. Ten-fold determinations with one and three tablets resulted in a benzbromaron content of 99.2 and 98.7 mg per tablet respectively. Increasing the number of tablets from one to three lowers the RSD from 1.36 to 0.88%. These results show an excellent agreement with the benzbromaron content indicated by the manufacturer (approx. 100 mg/tablet).Besides the presented Titrando/homogenizer combination, the other two members of the 815 Robotic Soliprep Sample Processor family offer comprehensive sample preparation possibilities within the fields of IC, HPLC, ICP or voltammetry.
8.000.6024EN	Fully automated sample preparation for the content determination of tablets (english)

8.000.6024 Fully automated sample preparation for the content determination of tablets
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8.000.6024 Fully automated sample preparation for the content determination of tablets
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8.000.6024 Fully automated sample preparation for the content determination of tablets