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with reports of a 751 GPD Titrino (predecessor of
799 GPT Titrino)
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In contrast, e.g. to HPLC, titration is an absolute
method and therefore requires no reference method. The
reaction processes are known; the titration takes place
strictly stoichiometrically and normally very rapidly.
If a titrant with a known titer is used then the content
of the sample can be determined directly. However, this
applies only to raw materials and not to formulations
that contain other components that could react with the
titrant in a similar or identical manner.
It does not make sense to qualify the individual components
of an analytical instrument or analysis system separately.
On the contrary, the complete titration system (titrator,
buret, electrode, titration evaluation, sample changer
if present) is subjected to a performance check. The
qualification of the titrator and the validation of the
titration method are carried out at the same time.
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5 to 10 different amounts of the sample - in this case
ephedrine hydrochloride (ephedrine x HCl, C10H15NO
x HCl) - are weighed to the nearest 0.1 mg (use a validated
balance). If a 20 mL buret is used then the sample weights
should be chosen to produce a titrant consumption between
2.5 and 15 mL. The sample is dissolved in the prescribed
solvent, the auxiliary solution is added and titration
is performed with c(titrant) = 0.1 mol/L.
1 mL c(titrant) = 0.1 mol/L corresponds to 20.17 mg
ephedrine x HCl
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